7132-68-5Relevant academic research and scientific papers
Synthesis and evaluation of N-alkyl-9-aminoacridines with antibacterial activity
Benoit, Adam R.,Schiaffo, Charles,Salomon, Christine E.,Goodell, John R.,Hiasa, Hiroshi,Ferguson, David M.
, p. 3014 - 3017 (2014/06/24)
A series of 9-alkylaminoacridines were synthesized and evaluated for activity against two strains of methicillin-resistant and one strain of methicillin-sensitive Staphylococcus aureus. Results are presented that show a clear structure activity relationship between the N-alkyl chain length and antibacterial activity with peak MIC99 values of 2-3 μM for alkyl chains ranging from 10 to 14 carbons in length. Although prior work has linked the function of acridine-based compounds to intercalation and topoisomerase inhibition, the present results show that 9-alkylaminoacridines likely function as amphiphilic membrane-active disruptors potentially in a similar manner as quaternary ammonium antimicrobials.
DIRECT SYNTHESIS OF SOME 9-AMINOALKYL ACRIDINES FROM 9-AMINO ACRIDINE USING PHASE TRANSFER CATALYSIS
Galy, Jean Pierre,Elguero, Jose,Vincent, Emile Jean
, p. 311 - 313 (2007/10/02)
A new method of preparation of 9-aminoalkyl acridines is described which avoid the use of 9-chloroacridine.Proton n.m.r. in trifluoroacetic acid easily differentiates 9-aminoalkyl from 9-amino 10-alkyl acridinium salts.Two dialkyl iminoacridanes have been
