7133-79-1

Basic information

• Product Name: 2H-1,3-Benzoxazine-2,4(3H)-dione, 3-(4-methylphenyl)-
• CAS NO: 7133-79-1
• Molecular Formula: C15H11NO3
• Molecular Weight: 253.257
• Mol File: 7133-79-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2H-1,3-Benzoxazine-2,4(3H)-dione, 3-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,3-Benzoxazine-2,4(3H)-dione, 3-(4-methylphenyl)-(7133-79-1)
• EPA Substance Registry System: 2H-1,3-Benzoxazine-2,4(3H)-dione, 3-(4-methylphenyl)-(7133-79-1)

Safety Data

• Hazardous Substances Data: 7133-79-1(Hazardous Substances Data)

Upstream product

• 24392-02-7 3-p-tolyl-2-p-tolylimino-2,3-dihydro-benz[e][1,3]oxazin-4-one 
• 7164-80-9 2-hydroxy-N-(p-tolyl)benzamide 
• 541-41-3 chloroformic acid ethyl ester 
• 88220-41-1 4-imino>-3-(4-methylphenyl)-2H-1,3-benzoxazin-2-one 
• 108-23-6 isopropyl chloroformate 
• 622-58-2 p-Tolylisocyanate 
• 88220-35-3 2-<(4-methylphenyl)aminocarbonyloxy>benzonitrile 
• 611-20-1 salicylonitrile 
• 533-58-4 2-Iodophenol 
• 201230-82-2 carbon monoxide 

Relevant articles and documents

Multivariate regression with substituent shift increments. IV. 2-(4-X-phenyl)-1,3-dihydro-2H-isoindole-1,3-diones and 3-(4-X-phenyl)-3,4-dihydro-2H-1,3-benzoxazine-2,4-diones

Two series of para disubstituted benzenes were studied: 2-(4-X-phenyl)-1,3-dihydro-2H-isoindole-1,3-diones (1) and 3-(4-X-phenyl)-3,4-dihydro-2H-1,3-benzoxazine-2,4-diones (2). Their 1H and 13C chemical shifts were correlated with substituent shift increments (SSI) aj and zj, respectively. For 13C chemical shifts, all four zj values, zj, zo, zm, and zp, were used to check the assignment and to find out possible variables for improvement of regression equations. Significant deviations from plain additivity were observed in the case of δH3 and δC3 chemical shifts. This can be explained by changes in diamagnetic anisotropy contribution induced by different twist of 4-substituent from the benzene plane caused by variable substituent in position 1.

NEW GROUPS OF POTENTIAL ANTITUBERCULOTICS: 3-ARYL-2H,4H-BENZOXAZINE-2,4-DIONES. COMPARISON OF THE TOPLISS APPROACH WITH REGRESSION ANALYSIS

3-Phenyl-2H,4H-benzoxazine-2,4-dione (I) and its derivatives II - XI, substituted on the phenyl ring, can be regarded as a new group of potential antituberculotics.Their activity increases with increasing electron-accepting properties of the substituents.Introduction of bromine into the position 6 also positively influences the activity.The compounds are active in vitro against Mycobacterium tuberculosis and M. kansasii.The activity of some of them (VIII, IX) exceeds that of commercial tuberculostatics used as standards.

Studies on 2-hydroxythiobenzamide and 2-hydroxythiobenzanilide. 1. Synthesis of the compounds

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