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Usage

Uses

Used in Organic Synthesis:
2,3-dihydro-1,4-ethanoquinoxaline is used as a building block in organic synthesis for creating various molecules and pharmaceutical drugs. Its bicyclic structure and nitrogen atoms provide a stable and reactive platform for the formation of new chemical entities.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2,3-dihydro-1,4-ethanoquinoxaline is utilized as a key component in the development of pharmaceutical drugs. Its ability to form stable complexes with other molecules makes it a valuable asset in designing and synthesizing novel therapeutic agents.
Used in Psychoactive Drug Research:
2,3-dihydro-1,4-ethanoquinoxaline has demonstrated potential as a psychoactive drug in research studies. Its unique chemical properties allow it to interact with specific receptors in the central nervous system, offering new avenues for the development of psychopharmacological agents.
Used in Coordination Chemistry:
As a ligand in coordination chemistry, 2,3-dihydro-1,4-ethanoquinoxaline forms complexes with transition metal ions. This ability to chelate metal ions is crucial in various applications, such as catalysis, materials science, and the development of new coordination compounds with specific properties.

Upstream product

• 145079-37-4 1-(2-hydroxyethyl)-benzo-1-azonium-4-azabicyclo<2.2.2>octene chloride 
• 75398-72-0 N-(β-bromoethyl)-1,2,3,4-tetrahydroquinoxaline 

Downstream Products

• 113849-99-3 1-p-nitrobenzylbenzo-1-azonium-4-azabicyclo<2.2.2>octene bromide 
• 138023-47-9 3',6'-Bis(trimethylsilyl)benzo<1',2'-b>-1,4-diazabicyclo<2.2.2>octene 
• 138023-46-8 3'-Formylbenzo<1',2'-b>-1,4-diazabicyclo<2.2.2>octene 
• 138023-42-4 3'-Hydroxybenzo<1',2'-b>-1,4-diazabicyclo<2.2.2>octene 
• 113850-06-9 1-p-nitrobenzyl-4-<2-(4-tert-butylphenylthio)ethyl>-1,2,3,4-tetrahydroquinoxaline 
• 113850-07-0 1-p-nitrobenzyl-4-(2-piperidinoethyl)-1,2,3,4-tetrahydroquinoxaline 
• 113850-04-7 1-benzyl-4-<2-(4-tert-butylphenylthio)ethyl>-1,2,3,4-tetrahydroquinoxaline 
• 113850-05-8 1-benzyl-4-(2-piperidinoethyl)-1,2,3,4-tetrahydroquinoxaline 
• 113850-03-6 1-benzyl-4-(2-methoxyethyl)-1,2,3,4-tetrahydroquinoxaline 
• 75398-72-0 N-(β-bromoethyl)-1,2,3,4-tetrahydroquinoxaline 
• 75398-68-4 N-(β-hydroxyethyl)-1,2,3,4-tetrahydroquinoxaline 
• 123629-25-4 1-(β-bromoethyl)-4-ethoxycarbonyl-1,2,3,4-tetrahydroquinoxaline 
• 98189-55-0 1-(2-Oxo-2-phenyl-ethyl)-2,3-dihydro-1,4-ethano-quinoxalin-1-ium; bromide 
• 113849-98-2 1-benzylbenzo-1-azonium-4-azobicyclo<2.2.2>octene bromide 

Relevant academic research and scientific papers

DIAZABICYCLOALKANES WITH BRIDGEHEAD NITROGEN ATOMS. 26. REACTIONS OF HYDROXYETHYL BENZO-1,4-DIAZABICYCLOOCTENES

By heating 1-(2-hydroxyethyl)benzo-1-azonium-4-azabicyclo-octene halides in anhydrous solvents or via thermolysis, opening of the bicycle occurs with formation of the corresponding N-(2-hydroxyethyl)-N'-(2-haloethyl)-1,2,3,4-tetrahydroquinoxalines.In the presence of base, fission of the hydroxyethyl group principally occurs.

DIAZABICYCLOALKANES WITH NITROGEN ATOMS IN THE NODAL POSITIONS. 4. INTRAMOLECULAR CYCLIZATION OF N-(β-X-ETHYL)-1,2,3,4-TETRAHYDROQUINOXALINES AND BEHAVIOR OF BENZO-1,4-DIAZABICYCLOOCTENES IN ACIDIC MEDIA

The intramolecular cyclization of N-(β-hydroxyethyl)-N'-acetyl-1,2,3,4-tetrahydroquinoxaline in refluxing HBr was investigated by liquid microcolumn chromatography.Under these conditions the amide group undergoes rapid hydrolysis, the hydroxy groups undergo relatively slow exchange by bromine, and the resulting N-(β-bromoethyl)-1,2,3,4-tetrahydroquinoxaline undergoes cyclization to give benzo-1,4-diazabicyclooctene.These transformations terminate with the establishment of equilibrium between VII and I. 7-Methyl-N-(β-chloroethyl)-1,2,3,4-tetrahydroquinoxaline similarly forms an equilibrium reaction mixture in HBr.The effect of various factors (the acid and bromide ion concentrations, the character of the acid, and the temperature) on the position of the equilibrium of the compounds obtained and on the occurence of side reactions (hydrolysis and dealkylation) was studied.