71402-67-0Relevant articles and documents
New trans/cis tetrahydroisoquinolines. 1. trans-2-Benzyl-3-(1-methyl-1h-pyrrol-2-yl)-4-substituted-1,2,3,4- tetrahydroisoquinolin-1-ones and corresponding tetrahydroisoquinolines
Kozekov,Koleva,Palamareva
, p. 229 - 236 (2002)
The reaction of homophthalic anhydride and N-(1-methyl-1H-pyrrol-2-yl-methylidene)-benzylamine in boiling benzene afforded as a main product the expected substituted trans-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid 5. The carboxylic group of 5 was transformed in four steps into cyclic amino-methyl groups yielding numerous new tetrahydroisoquinolinones 11a-j incorporating a given fragment of pharmacological interest. Reduction of 11a-j was studied.
Mechanistic Investigation of Castagnoli-Cushman Multicomponent Reactions Leading to a Three-Component Synthesis of Dihydroisoquinolones
Howard, Sara Y.,Di Maso, Michael J.,Shimabukuro, Kristin,Burlow, Noah P.,Tan, Darlene Q.,Fettinger, James C.,Malig, Thomas C.,Hein, Jason E.,Shaw, Jared T.
, p. 11599 - 11607 (2021/09/02)
The mechanisms for the three- and four-component variants of the Castagnoli-Cushman reaction (CCR) have been investigated. A series of crossover experiments were conducted to probe the structure and reactivity of known amide-acid intermediates for the thr
Synthesis of new trans-2-benzyl-3-(furan-2-yl)-4-substituted-1,2,3,4- tetrahydroisoquinolinones
Kandinska, Meglena I.,Kozekov, Ivan D.,Palamareva, Mariana D.
, p. 403 - 414 (2007/10/03)
The reaction of homophthalic anhydride and N-(furan-2-yl-methylidene)- benzylamine in different solvents and varying temperatures was studied in detail. Mixtures of the expected trans- and cis-1,2,3,4-tetrahydroisoquinoline- 4-carboxylic acids trans-5 and
