714248-98-3

Basic information

• Product Name: 7-({[(4-azepan-1-yl)phenyl]amino}methyl)-1,4-diazepane-1-carboxylate
• Synonyms: 7-({[(4-azepan-1-yl)phenyl]amino}methyl)-1,4-diazepane-1-carboxylate
• CAS NO: 714248-98-3
• Molecular Weight: 355.483
• Mol File: 714248-98-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-({[(4-azepan-1-yl)phenyl]amino}methyl)-1,4-diazepane-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 7-({[(4-azepan-1-yl)phenyl]amino}methyl)-1,4-diazepane-1-carboxylate(714248-98-3)
• EPA Substance Registry System: 7-({[(4-azepan-1-yl)phenyl]amino}methyl)-1,4-diazepane-1-carboxylate(714248-98-3)

Safety Data

• Hazardous Substances Data: 714248-98-3(Hazardous Substances Data)

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 13663-23-5 1-(4-Nitrophenyl)-perhydroazepin 
• 179756-49-1 7-formyl-2-naphthalene-carbonitrile 
• 57356-18-0 4-(azepan-1-yl)aniline 

Downstream Products

• 714249-09-9 N-(4-azepan-1-ylphenyl)-N-[(7-cyano-2-napthyl)methyl]methanesulfonamide 

Relevant articles and documents

Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity

Factor Xa (fXa) is a serine protease involved in the coagulation cascade, which has received great interest as a potential target for the development of new antithrombotic drugs. Herein we report a novel series of fXa inhibitors in which the 1,4-diazepane moiety was designed to interact with the S4 aryl-binding domain of the fXa active site. Compound 13 (YM-96765) showed potent fXa inhibitory activity (IC50=6.8nM) and effective antithrombotic activity without prolonging bleeding time.