13663-23-5

Basic information

• Product Name: hexahydro-1-(4-nitrophenyl)-1H-azepine
• Synonyms: hexahydro-1-(4-nitrophenyl)-1H-azepine;1-(4-Nitrophenyl)hexahydro-1H-azepine;1H-Azepine, hexahydro-1-(4-nitrophenyl)-;Einecs 237-144-0;N-(4'-Nitrophenyl)hexamethylenimine
• CAS NO: 13663-23-5
• Molecular Formula: C₁₂H₁₆N₂O₂
• Molecular Weight: 220.26764
• EINECS: 237-144-0
• Mol File: 13663-23-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 377.4°C at 760 mmHg
• Flash Point: 182.1°C
• Appearance: /Solid
• Density: 1.151g/cm³
• Vapor Pressure: 6.76E-06mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: hexahydro-1-(4-nitrophenyl)-1H-azepine(CAS DataBase Reference)
• NIST Chemistry Reference: hexahydro-1-(4-nitrophenyl)-1H-azepine(13663-23-5)
• EPA Substance Registry System: hexahydro-1-(4-nitrophenyl)-1H-azepine(13663-23-5)

Safety Data

• TSCA: Yes
• HazardClass: 8
• Hazardous Substances Data: 13663-23-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H16N2O2/c15-14(16)12-7-5-11(6-8-12)13-9-3-1-2-4-10-13/h5-8H,1-4,9-10H2

Upstream product

• 111-49-9 hexamethylene imine 
• 100-00-5 4-chlorobenzonitrile 
• 55259-21-7 2-azepan-1-yl-5-nitro-benzoic acid 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 444002-57-7 N-(4-nitrophenyl)caprolactam 
• 714249-09-9 N-(4-azepan-1-ylphenyl)-N-[(7-cyano-2-napthyl)methyl]methanesulfonamide 
• 714248-98-3 7-({[(4-azepan-1-yl)phenyl]amino}methyl)-1,4-diazepane-1-carboxylate 
• 57356-18-0 4-(azepan-1-yl)aniline 

Relevant articles and documents

KV11.1-3.1 INHIBITING METHODS AND COMPOSITIONS

Compounds of formula (I), formula (II), or formula (III) and their use for treating a neurological or psychiatric disorder, or treating symptoms associated with a neurological or psychiatric disorder, mediated by Kv11.1-3.1 containing potassium channels, including schizophrenia, are disclosed.

Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity

Factor Xa (fXa) is a serine protease involved in the coagulation cascade, which has received great interest as a potential target for the development of new antithrombotic drugs. Herein we report a novel series of fXa inhibitors in which the 1,4-diazepane moiety was designed to interact with the S4 aryl-binding domain of the fXa active site. Compound 13 (YM-96765) showed potent fXa inhibitory activity (IC50=6.8nM) and effective antithrombotic activity without prolonging bleeding time.

Aminoalkyl-substituted aromatic bicyclic compounds, methods for their preparation and their use as pharmaceuticals

The present invention relates to aminoalkyl-substituted aromatic bicyclic compounds of formula I, which are valuable pharmaceutically active compounds that are suitable, for example, for the treatment of obesity, type II diabetes, arteriosclerosis, high blood pressure, paresthesia, depression, anxiety, anxiety neuroses, schizophrenia, disorders associated with the circadian rhythm, and drug abuse, as well as normalizing lipid metabolism.