714273-92-4

Upstream product

• 5197-62-6 2-[2-(chloroethoxy)ethoxy]ethanol 
• 99-93-4 4-Hydroxyacetophenone 
• 77544-68-4 8-tosyloxy-3,6-dioxaoctanol 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 365134-29-8 2-[2-{2-(4-ethynylphenoxy)ethoxy}ethoxy]ethanol 

Downstream Products

• 497165-74-9 4-N,N-dihexadecylamino-4'-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}chalcone 
• 958456-73-0 1-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenyl)ethanone 
• 247056-18-4 4-N,N-dihexadecylamino-4'-{2-[2-(2-iodoethoxy)ethoxy]ethoxy}chalcone 

Relevant academic research and scientific papers

Photoacoustic Probes for Ratiometric Imaging of Copper(II)

Photoacoustic tomography has emerged as a promising alternative to MRI and X-ray scans in the clinical setting due to its ability to afford high-resolution images at depths in the cm range. However, its utility has not been established in the basic research arena owing to a lack of analyte-specific photoacoustic probes. To this end, we have developed acoustogenic probes for copper(II)-1 and -2 (APC-1 and APC-2, a water-soluble congener) for the chemoselective visualization of Cu(II), a metal ion which plays a crucial role in chronic neurological disorders such as Alzheimer's disease. To detect Cu(II), we have equipped both APCs with a 2-picolinic ester sensing module that is readily hydrolyzed in the presence of Cu(II) but not by other divalent metal ions. Additionally, we designed APC-1 and APC-2 explicitly for ratiometric photoacoustic imaging by using an aza-BODIPY dye scaffold exhibiting two spectrally resolved NIR absorbance bands which correspond to the 2-picolinic ester capped and uncapped phenoxide forms. The normalized ratiometric turn-on responses for APC-1 and APC-2 were 89- and 101-fold, respectively.

Chemistry and photochemistry of anthocyanins and related compounds: A thermodynamic and kinetic approach

Anthocyanins are identified by the respective flavylium cation, which is only one species of a multistate of different molecules reversibly interconverted by external inputs such as pH, light and temperature. The flavylium cation (acidic form) is involved

Hydration of aromatic terminal alkynes catalyzed by iron(III) sulfate hydrate under chlorine-free conditions

The hydration of aromatic terminal alkynes performed in acetic acid in the presence of catalytic hydrate ironIII sulfate, Fe2(SO 4)3·nH2O (4-9 mol %), yields the derived aryl methyl ketones with good to excellent yields. Under comparable conditions (18 mol %, 95 C, 24 h), bifunctional substrates were transformed into the monoacetyl or the diacetyl derivatives, depending on the structure of the aromatic diyne. The reaction is compatible with aryl substituents of different nature and ring positions, including hydroxyl, carbonyl groups, and cumulated hydrocarbons. The soft character of the non nucleophilic sulfate anion allows for activation of the triple bond toward carbonoxygen bond formation in the Br?nsted acidic medium. The proposed protocol is based on readily available and non toxic materials, in the absence of chlorine atoms in either the solvent or the metal catalyst.

COMPOSITION FOR DIAGNOSIS OF AMYLOID-RELATED DISEASE

There is provided a composition comprising a compound represented by general formula (I), wherein Rl represents a 5-iodothiophen-2-yl group or the like, and R2 represents a 4-dimethylaminophenyl group or the like. This composition is useful for diagnosis of an amyloid-related disease such as Alzheimer's disease because the compound has high binding specificity to amyloid β protein, high permeability through the blood-brain barrier, and a property of being rapidly eliminated from sites other than senile plaques in the brain.

COMPOSITION FOR DIAGNOSING AMYLOID-RELATED DISEASE

There is provided a composition comprising a compound represented by general formula (I), wherein R1 represents a 5-iodothiophen-2-yl group or the like, and R2 represents a 4-dimethylaminophenyl group or the like. This composition is useful for diagnosis of an amyloid-related disease such as Alzheimer's disease because the compound has high binding specificity to amyloid β protein, high permeability through the blood-brain barrier, and a property of being rapidly eliminated from sites other than senile plaques in the brain.

Fluoro-pegylated chalcones as positron emission tomography probes for in vivo imaging of β-amyloid plaques in Alzheimer's disease

This paper describes the synthesis and biological evaluation of fluoro-pegylated (FPEG) chalcones for the imaging of β-amyloid (Aβ) plaques in patients with Alzheimer's disease (AD). FPEG chalcone derivatives were prepared by the aldol condensation reacti

Micelles of lipid-oligonucleotide conjugates: Implications for membrane anchoring and base pairing

This report examines the organization properties of new fluorescent DNA-lipids, either alone in water or in interaction with 1-octyl-?2-D- glucopyranoside micelles or egg phosphatidylcholine vesicles. We first describe the design and the syntheses of the