71434-06-5

Upstream product

• 71434-05-4 Di-tert-butyl(2-Methoxyethyl)malonat 
• 100-07-2 4-methoxy-benzoyl chloride 
• 23462-75-1 5,6-dihydro-2H-pyran-3(4H)-one 
• 696-62-8 para-iodoanisole 

Downstream Products

• 71433-84-6 1-(1-Chloro-4-methoxy-butyl)-4-methoxy-benzene 
• 71433-85-7 C₁₂H₁₆⁽²⁾HClO₂ 
• 71433-86-8 C₁₂H₁₅⁽²⁾H₂ClO₂ 

Relevant academic research and scientific papers

Catalytic Ring-Opening of Cyclic Alcohols Enabled by PCET Activation of Strong O-H Bonds

We report a new photocatalytic protocol for the redox-neutral isomerization of cyclic alcohols to linear ketones via C-C bond scission. Mechanistic studies demonstrate that key alkoxy radical intermediates in this reaction are generated via the direct homolytic activation of alcohol O-H bonds in an unusual intramolecular PCET process, wherein the electron travels to a proximal radical cation in concert with proton transfer to a weak Br?nsted base. Effective bond strength considerations are shown to accurately forecast the feasibility of alkoxy radical generation with a given oxidant/base pair.