71441-45-7

Usage

InChI:InChI=1/C24H30/c1-17-7-9-19(10-8-17)15-18(2)20-11-12-21-22(16-20)24(5,6)14-13-23(21,3)4/h7-12,15-16H,13-14H2,1-6H3/b18-15+

Upstream product

• 6683-46-1 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydro-naphthalene 
• 104-87-0 4-methyl-benzaldehyde 
• 75-36-5 acetyl chloride 
• 69251-25-8 5,6,7,8-tetrahydro-α,5,5,8,8-pentamethyl-2-naphthalene methanol 
• 69251-26-9 2-(bromoethyl)-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene 
• 17610-21-8 1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)ethanone 
• 69251-24-7 [1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-ethyl]-triphenylphosphonium bromide 

Relevant academic research and scientific papers

Stilbene derivatives

This invention is directed to 5,6,7,8-tetrahydro-naphthyl or indanyl stilbene derivatives which are useful as tumor inhibiting agents, in the treatment of neoplasms, dermatological conditions and rheumatic illnesses.

Arotinoids, a new class of highly active retinoids

The synthesis and biological activity of new aromatic retinoids are reported. The most active ones belong to a chemical class of compounds, which we have termed 'arotinoids'. For the compound p-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-propenyl)]-benzoic acid ethyl ester, a therapeutic potency in the antipapilloma test was found which exceeds that of retinoic acid by a factor of 8000, while the concurrently observed toxic hypervitaminosis A effects are only increased by a factor of 800. The structural relationship of the arotinoids with retinoic acid is demonstrated; the arotinoids contain the retinoic acid carbon skeleton in a fixed cisoid geometric conformation.