714568-34-0

Upstream product

• 714568-47-5 4-(2-azidoethyl)benzonitrile 
• 107-15-3 ethylenediamine 
• 172348-86-6 tert-butyl N-[2-(4-cyanophenyl)ethyl]carbamate 
• 120157-97-3 t-butyl 2-(4-bromophenyl)ethylcarbamate 
• 73918-56-6 4-Bromophenethylamine 
• 69395-13-7 4-(2-hydroxyethyl)benzonitrile 
• 524743-24-6 ethyl 4-(2-phthalimidoethyl)benzoate 
• 308846-03-9 4-[2-(1,3-dioxoisoindolin-2-yl)ethyl]benzonitrile 
• 132224-93-2 [(4-cyanophenyl)methyl]methanamine 
• 942613-38-9 2-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-ethyl}-isoindole-1,3-dione 
• 1211569-77-5 tert-butyl {2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}carbamate 

Downstream Products

• 1242847-69-3 N-[2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl]-2-[2-[(6-methoxynaphthalen-2-yl)sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]acetamide 
• 1374416-64-4 C₃₅H₃₆N₄O₃S 
• 1374416-57-5 C₂₈H₂₈Cl₂N₄O₃S 
• 1374416-56-4 C₂₈H₂₈Cl₂N₄O₃S 
• 1374416-55-3 C₂₈H₂₈Cl₂N₄O₃S 
• 1211570-02-3 N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}-5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxamide 
• 1055983-94-2 methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-{[3-(4-cyanophenyl)propyl]thio}propanoate 

Relevant academic research and scientific papers

Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists

A new series of quinolinyl- and phenantridinyl-acetamides were synthesizer and evaluated against bradykinin B1 receptor. In vitro metabolic stability data were reported for the key compounds.The analgesic effect of compound 20 from the phenantridine series was proved in-vivo.

SULFONYLATED TETRAHYDROAZOLOPYRAZINES AND THEIR USE AS MEDICINAL PRODUCTS

The present invention relates to sulfonylated tetrahydroazolopyrazines, methods for the preparation thereof, medicinal products containing these compounds and the use of substituted indole compounds for the preparation of medicinal products (Formula I).

NEW PHENANTHRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS

The present invention relates to new phenanthridine derivatives of formula (I) wherein R1 is hydrogen atom or C1-C4 alkyl group; R2 is selected from (1) hydrogen atom; with the proviso that R1 and Rs

2-QUINOXALINONE DERIVATIVES AS BRADYKININ ANTAGONISTS AND NOVEL COMPOUNDS

2-Quinoxalinone derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

NOVEL QUINOXALINONE DERIVATIVES AS BRADYKININ B1 ANTAGONISTS

2-Quinoxalinone derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.