71458-06-5

Usage

Chemical Properties

White Crysstalline

Upstream product

• 82575-70-0 trans-4-cyclohexanol 
• 71458-12-3 trans-4-n-propyl-1-bromomethylcyclohexane 
• 77866-58-1 trans-4-propylcyclohexanol 
• 67589-88-2 trans-4-propylcyclohexanecarbonyl chloride 
• 38289-27-9 trans-4-propyl-cyclohexanecarboxylic acid 

Downstream Products

• 71458-12-3 trans-4-n-propyl-1-bromomethylcyclohexane 
• 85324-89-6 1-Biphenyl-4-yl-2-(4-propyl-cyclohexyl)-ethanone 
• 86504-67-8 1-(4'-Fluoro-biphenyl-4-yl)-2-(4-propyl-cyclohexyl)-ethanone 
• 86504-66-7 1-(4'-Chloro-biphenyl-4-yl)-2-(4-propyl-cyclohexyl)-ethanone 
• 71458-26-9 1-(4'-Bromo-biphenyl-4-yl)-2-(4-propyl-cyclohexyl)-ethanone 
• 1023967-90-9 C₁₀H₁₉BrMg 

Relevant academic research and scientific papers

CARBAMATE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS

Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.

Process for the preparation of liquid crystalline ethers

Preparation of 4- or 4'-mono- and 4,4'-di-substituted (bi)cyclohexyl (bi)cyclohexylmethyl ethers (I) by reducing corresponding (bi)cyclohexyl (cyclohexyl)cyclohexanoates (II) comprises reacting 1 molar equivalent (II) with 2-6 molar equivalent of an optionally mono-, di- or tri-substituted silane (III) in a free radical chain reaction, optionally in a solvent. Preparation of 4- or 4'-mono- and 4,4'-di-substituted (bi)cyclohexyl (bi)cyclohexylmethyl ethers (I) by reducing corresponding (bi)cyclohexyl (cyclohexyl)cyclohexanoates (II) comprises reacting 1 molar equivalent (II) with 2-6 molar equivalent of an optionally mono-, di- or tri-substituted silane R1>1>R1>2>R1>3>SiH (III) of the following formulae in a free radical chain reaction, optionally in a solvent: [Image] [Image] R1>, R2>1-12C alkyl or 2-12C alkenyl, which is an unsubstituted or has one CN or CF3 substituent or at least one halogen substituent and may have CH2 group(s) replaced by -O-, -S-, cyclopropan-1,2-diyl or cyclobutan-1,3-diyl, without directly linked O atoms, or H in one case only; R3>-R6>H, halogen, methyl or CN; R11>-R13>Cl in at least one case, otherwise H, 1-8C alkyl, 1-8C alkoxy, cyclohexyl, methylcyclohexyl, cyclopentyl or phenyl or R1>1>R1>2> is a -(CH2)r- group; m, n : 0 or 1; r : 4 or 5 An independent claim is included for the preparation of symmetric di-(bi)cyclohexyl(alkyl) ethers (XXI) with 1-3 C alkyl groups: [Image] p, q : 0, 1, 2 or 3; p+q : 1, 2 or 3.

The Synthesis and Liquid-Crystal Transition Temperatures of Some Fluoro-Substituted Benzonitriles

Various laterally fluoro-substituted benzonitriles have been prepared containing a trans-4-(n-alkyl)cyclohexane ring linked to the 4-position of the benzonitriles either through a methyleneoxy (-CH2O-) or an ethylene (-CH2CH2-) bridge.The bridging group links the benzonitrile and cyclohexane rings either directly or through an additional 1,4-bonded cyclohexane or benzene ring.The synthesis and liquid-crystal transition temperatures of these new compounds are described.In several cases the nematic-isotropic transition temperatures of F-substituted benzonitriles are found to be higher than those of the non-laterally substituted analogues.

The Properties of Liquid Crystal Materials Incorporating the -CH2O- Inter-ring Linkage

To establish more securely the influence of the -CH2O- inter-ring linkage upon the properties of mesogens of both high and low dielectric anisotropy, a range of ethers with the following general structure has been prepared and their properties examined. The thermal and electro-optic properties of the compounds are discussed, and comparisons made where possible with analogous materials incorporating the -CH2CH2- linkage.

SYNTHESIS AND SOME PHYSICAL PROPERTIES OF 1-CYCLOHEXYL-2-(4 double prime -HALOBIPHENYL-4 prime -yl)ETHANES.

A series of 1-(trans-4 prime -n-alkylcyclohexyl)-2-(4 double prime -halobiphenyl-4 prime -yl)ethanes, which show nematic phases, was prepared. Their transition temperatures, enthalpies and entropies were measured. Their bulk viscosities, birefringences and dielectric constants were determined by extrapolation. The bulk viscosity as a function of the third power of the van der Waals radius of the halogeno group, the birefringence as a function of the van der Waals radius of the halogeno group, and the dielectric constants as a function of the dipole moment of the halogeno group are discussed for the 1-(trans-4 prime -n-propylcyclohexyl)-2-(4 double prime -halobiphenyl-4 prime -yl)ethanes.

1-(TRANS-4 prime -N-ALKYLCYCLOHEXYL)-2-(4 double prime -CYANOPHENYL)ETHANES - A NEW SERIES OF STABLE NEMATOGENS OF POSITIVE DIELECTRIC ANISOTROPY.

The synthesis and some important properties of the 1-(trans-4 prime -n-alkylcyclohexyl)-2-(4 double prime -cyanophenyl)ethanes - where n-alkyl equals C//1 to C//7 - are described.