7147-29-7

Upstream product

• 7735-38-8 13-hydroxytridecanoic acid 
• 186581-53-3 diazomethane 
• 3927-59-1 tridecanedioic acid monomethyl ester 
• 33240-34-5 cyclopentylmagnesium bromide 
• 64-17-5 ethanol 
• 1608-77-1 methyl 12-formyldodecanoate 
• 67-56-1 methanol 
• 54894-30-3 11-acetoxyundecanoic acid 
• 88229-68-9 Lithium 11-bromoundecoxide 
• 112-86-7 cis-13-docosenoic acid 
• 88229-67-8 12-(5,5-Dimethyl-4,5-dihydro-oxazol-2-yl)-dodecan-1-ol 

Downstream Products

• 4568-88-1 (S)-15,16-dihydroxy-hexadecanoic acid methyl ester 

Relevant academic research and scientific papers

Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound

A steroid ester compound of a terminally-fluorinated alkyl fatty acid, a steroid compound having bis(trifluoromethyl)phenyl group, a phosphatidylserine compound having a terminally-fluorinated alkyl group, a glyceride compound having bis(trifluoromethyl phenyl group, or a glyceride compound having a terminally-fluorinated alkyl group. A vascular lesion can be selectively imaged by using a contrast medium comprising a liposome containing said compound or a salt thereof.

1,3-minus;GLYCERIDE COMPOUND HAVING TWO IODOPHENYL GROUPS

A compound represented by the following general formula (I) or a salt thereof: wherein Ar1 and Ar2 independently represent a substituted or unsubstituted aryl group having at least one iodine atom as a substituent; L1 and

Studies on mimicry of naturally occurring annonaceous acetogenins: Non-THF analogues leading to remarkable selective cytotoxicity against human tumor cells

A class of structurally simplified analogues of the naturally occurring annonaceous acetogenins were developed, amongst which some non-THF analogues showed remarkable cytotoxicities against tumor cell lines, as well as good selectivity between human tumor cells and normal cells. The synthetic routes were significantly shortened because of the removal of the chiral centers bearing the THF rings on the natural templates. This simplification also provides access to the parallel synthesis of these mimics by a combinatorial strategy. The remaining stereogenic centers at the positions α to the ethereal links were introduced by the Chiron approach from the easily accessible chiral building blocks 6a and/or 6b, made in turn from L-ascorbic acid or Dmannitol, while the one in the butenolide segment was taken from L-lactate. All four diastereomeric non-THF analogues 2a-2d showed remarkable activity against the HCT-8 cell line, and better differentiation was found when testing against the HT-29 cell line. It was also discovered that both the butenolide and ethylene glycol subunits play essential roles in the cytotoxicities against tumor cell lines, while the 10-substituted hydroxy group and the absolute configuration of methyl group at the butenolide moiety are less important for their activity.

Enantiopure simple analogues of annonaceous acetogenins with remarkable selective cytotoxicity towards tumor cell lines

Structure simplification with conservation of the essential functionalities for biological activity has been achieved with the design and synthesis of four analogues of annonaceous acetogenins. The compounds ((15 R/S, 24 R/S)-1) are easily synthesized wit

Hydrogenation of carboxylic acids using bimetallic catalysts consisting of Group 8 to 10, and Group 6 or 7 metals

Hydrogenation of carboxylic acids to alcohols was effectively catalyzed by bimetallic systems consisting of Group 8 to 10 late transition-metals, and Group 6 or 7 early transition-metal carbonyls. These catalysts easily converted α,ω-dicarboxylic acid monoesters into ω-hydroxyalkanoic esters in good yields.

Studies in Lipid Mimics. Synthesis and Carbon-13 Relaxation Time Measurements (T1 Values) of Methyl Esters of ω-(2-Anthryl)alkanoic Acids

The syntheses of methyl 12-(2-anthryl)dodecanoate, methyl 14-(2-anthryl)tetradecanoate, and methyl 17-(2-anthryl)heptadecanoate have been achieved.Both 1H and 13C chemical shifts and T1 values for carbons in the systems have been recorded.By using selected heteronuclear decoupling and performing heteronuclear correlated 2-dimensional (HETCOR-2-D) experiments, it was possible to assign protons to specific carbons in most cases.