7147-33-3

Basic information

• Product Name: ETHYL A-ETHOXYOXALYLPHENYL ACETATE
• Synonyms: Nsc25342;ETHYL A-ETHOXYOXALYLPHENYL ACETATE;Diethyl oxophenylbutanedioate;Ethyl -ethoxyoxalylphenylacetate
• CAS NO: 7147-33-3
• Molecular Formula: C₁₄H₁₆O₅
• Molecular Weight: 264.27
• Mol File: 7147-33-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 367.6°C at 760 mmHg
• Flash Point: 161°C
• Appearance: /
• Density: 1.168g/cm³
• Vapor Pressure: 1.35E-05mmHg at 25°C
• Refractive Index: 1.505
• PKA: 8.01±0.46(Predicted)
• CAS DataBase Reference: ETHYL A-ETHOXYOXALYLPHENYL ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL A-ETHOXYOXALYLPHENYL ACETATE(7147-33-3)
• EPA Substance Registry System: ETHYL A-ETHOXYOXALYLPHENYL ACETATE(7147-33-3)

Safety Data

• Hazardous Substances Data: 7147-33-3(Hazardous Substances Data)

Usage

General Description

ETHYL A-ETHOXYOXALYLPHENYL ACETATE is a chemical compound commonly used as a flavoring agent and fragrance ingredient in various consumer products. It is a clear, colorless liquid with a sweet, floral aroma. ETHYL A-ETHOXYOXALYLPHENYL ACETATE is used in the production of perfumes, soaps, cosmetics, and other scented products. However, it should be handled with caution as it may cause skin and eye irritation, and could be harmful if swallowed or inhaled.ETHYL A-ETHOXYOXALYLPHENYL ACETATE is also known by several other names, including ethyloxalylphenylacetate and ethyl 2-ethoxyacetylbenzoate.

InChI:InChI=1/C14H16O5/c1-3-18-13(16)11(10-8-6-5-7-9-10)12(15)14(17)19-4-2/h5-9,11H,3-4H2,1-2H3

Upstream product

• 101-97-3 Ethyl 2-phenylethanoate 
• 95-92-1 oxalic acid diethyl ester 
• 60-29-7 diethyl ether 
• 119174-42-4 2-ethoxy-2-oxoacetic anhydride 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 22286-82-4 2-phenyl-acrylic acid ethyl ester 
• 83-13-6 diethyl 2-phenylmalonate 
• 1309477-15-3 C₃₁H₃₄N₂O₂ 
• 1309477-17-5 C₃₃H₃₈N₂O₂ 
• 1309477-19-7 C₃₅H₄₂N₂O₂ 
• 1309477-21-1 C₃₇H₄₆N₂O₂ 
• 1309477-23-3 C₃₉H₅₀N₂O₂ 
• 37818-48-7 2-Phenyl-propanedioyl dichloride 
• 59530-33-5 dipentachlorophenyl phenylmalonate 
• 56431-38-0 3,6-Dihydro-1,2,3,5-tetraphenyl-1-pyrimidinium-4-olat 
• 63286-01-1 2-methyl-5-oxo-4-phenyl-2,5-dihydro-isoxazole-3-carboxylic acid anilide 
• 63285-99-4 2-methyl-5-oxo-4-phenyl-2,5-dihydro-isoxazole-3-carbonyl chloride 
• 63285-98-3 2-methyl-5-oxo-4-phenyl-2,5-dihydro-isoxazole-3-carboxylic acid 
• 63286-00-0 2-methyl-5-oxo-4-phenyl-2,5-dihydro-isoxazole-3-carboxylic acid amide 

Relevant articles and documents

Asymmetric Synthesis of Spiropyrazolones by Rhodium-Catalyzed C(sp2)?H Functionalization/Annulation Reactions

Rhodium-catalyzed C(sp2)?H functionalization reactions of 4-aryl-5-pyrazolones followed by [3+2] annulation reactions with alkynes provide rapid access to highly enantioenriched five-membered-ring 4-spiro-5-pyrazolones. The use of a chiral SCpRh catalyst enabled the synthesis of a large range of spiropyrazolones with all-carbon quaternary stereogenic centers in up to 99 % yield and 98 % ee from readily available substrates.

Studies on non-thiazolidinedione antidiabetic agents. 1. Discovery of novel oxyiminoacetic acid derivatives

A novel series of oxyiminoacetic acid derivatives were synthesized in an effort to develop a potent antidiabetic agent, which does not contain the 2,4-thiazolidinedione moiety. These compounds were evaluated for glucose and lipid lowering effects in genetically obese and diabetic KKAy mice. Several of the compounds showed strong antidiabetic activity, including functional potency at peroxisome proliferator-activated receptor (PPAR)-γ. (Z)-2-[4-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino]-2-(4- phenoxyphenyl)acetic acid (25) significantly reduced plasma glucose (33%, p0.01) and plasma triglycelide levels (43%, p0.01) even at a dosage of 0.001% in diet. Pharmacokinetic analyses of 25 are also reported.

Intramolecular Carbenoid Reactions of Pyrrole Derivatives. A Total Synthesis of (+/-)-Ipalbidine

A mew method for alkaloid synthesis is described.The rhodium(II)-acetate-catalyzed decomposition of 3-(4-acetoxyphenyl)-1-diazo-4-(pyrrol-1-yl)-2-butanone (5d) gave 6-(4-acetoxyphenyl)-5,6-dihydro-7(8H)-indolizinone (6d) in 82percent yield via an intramolecular carbenoid reaction.The latter compound was converted in four steps in 13percent overall yield to (+/-)-ipalbidine (1b).