7149-45-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(pyrrolidin-1-ylmethyl)pyridin-3-ol is used as a building block for the synthesis of various organic compounds due to its unique structure and reactivity. It serves as a valuable tool in creating diverse chemical entities with potential medical applications.
Used in Drug Development:
2-(pyrrolidin-1-ylmethyl)pyridin-3-ol is used as a drug intermediate or precursor for the development of novel therapeutic agents. Its presence in the molecule suggests potential biological activity, making it an interesting target for further research and development in the pharmaceutical field.
Used in Organic Synthesis:
2-(pyrrolidin-1-ylmethyl)pyridin-3-ol is used as a key component in the synthesis of complex organic molecules, leveraging its unique structural features to facilitate the formation of new chemical entities with potential applications in various industries.

Upstream product

• 123-75-1 pyrrolidine 
• 109-00-2 3-HYDROXYPYRIDINE 
• 50-00-0 formaldehyd 

Downstream Products

• 125130-49-6 trans-1-<(3,4-dichlorophenyl)acetyl>-3-hydroxy-2-(1-pyrrolidinylmethyl)piperidine 
• 125130-49-6 cis-1-<(3,4-dichlorophenyl)acetyl>-3-hydroxy-2-(1-pyrrolidinylmethyl)piperidine 

Relevant academic research and scientific papers

HETEROAROMATIC ELECTROPHILES AND METHODS OF USING THEREOF

Disclosed herein are compounds, compositions, and methods for reactivating or realkylating aged acetylcholinesterase inhibited by or conjugated to the organophosphorus compound. The organophosphorus compound can be a nerve agent. The acetylcholinesterase can be in the central nerve system (CNS) and/or the peripheral nervous system (PNS) of a subject. Accordingly, methods for ameliorating, diminishing, reversing, treating or preventing the toxic effects of an organophosphorus compound in a subject are provided herein. Methods for prophylactic or therapeutic treatment of exposure to an organophosphorus nerve agent are also provided.

Demonstration of in Vitro Resurrection of Aged Acetylcholinesterase after Exposure to Organophosphorus Chemical Nerve Agents

After the inhibition of acetylcholinesterase (AChE) by organophosphorus (OP) nerve agents, a dealkylation reaction of the phosphylated serine, referred to as aging, can occur. When aged, known reactivators of OP-inhibited AChE are no longer effective. Realkylation of aged AChE may provide a route to reversing aging. We designed and synthesized a library of quinone methide precursors (QMPs) as proposed realkylators of aged AChE. Our lead compound (C8) from an in vitro screen successfully resurrected 32.7 and 20.4% of the activity of methylphosphonate-aged and isopropyl phosphate-aged electric-eel AChE, respectively, after 4 days. C8 displays properties of both resurrection (recovery from the aged to the native state) and reactivation (recovery from the inhibited to the native state). Resurrection of methylphosphonate-aged AChE by C8 was significantly pH-dependent, recovering 21% of activity at 4 mM and pH 9 after only 1 day. C8 is also effective against isopropyl phosphate-aged human AChE.