7151-77-1

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 4-methanesulfonamidobenzoate is used as an intermediate in the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs) for its analgesic, anti-inflammatory, and antipyretic properties. It plays a crucial role in the production of widely used medications such as aspirin and ibuprofen, contributing to their effectiveness in managing pain, inflammation, and fever.
Used in Research Laboratories:
In the scientific community, ethyl 4-methanesulfonamidobenzoate is utilized in research settings for various chemical and biological studies. Its unique properties and reactivity make it a valuable tool for exploring new chemical pathways and potential therapeutic applications, further expanding its relevance in the advancement of medical and chemical research.

InChI:InChI=1/C10H13NO4S/c1-3-15-10(12)8-4-6-9(7-5-8)11-16(2,13)14/h4-7,11H,3H2,1-2H3

Upstream product

• 3144-09-0 methanesulfonamide 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 124-63-0 methanesulfonyl chloride 
• 94-09-7 p-aminoethylbenzoate 
• 5798-75-4 Ethyl 4-bromobenzoate 

Downstream Products

• 183430-84-4 ethyl 3-nitro-4-[(methylsulfonyl)amino]benzoate 
• 7151-76-0 4-(methylsulfonamido)benzoic acid 
• 774238-85-6 N-[4-(hydroxymethyl)phenyl]methanesulfonamide 
• 183430-85-5 ethyl 3-amino-4-[(methylsulfonyl)amino]benzoate 

Relevant academic research and scientific papers

ORGANIC REACTIONS CARRIED OUT IN AQUEOUS SOLUTION IN THE PRESENCE OF A HYDROXYALKYL(ALKYL)CELLULOSE OR AN ALKYLCELLULOSE

The present invention relates to a method of carrying out an organic reaction in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose.

OXABOROLE ESTERS AND USES THEREOF

The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas Disease and African Animal Trypanosomosis.

Palladium-Catalyzed cascade sp2 c?H bond functionalizations allowing one-Pot access to 4?Aryl-1,2,3,4-tetrahydroquinolines from n?Allyl?N?arylsulfonamides

We have developed a palladium-catalyzed cascade reaction allowing an efficient synthesis of 4-aryl-1,2,3,4-tetrahydroquinolines from N-allyl-N-arylsulfonamides and benzenesulfonyl chlorides. In this transformation, two C(sp2)?C(sp3) bonds were formed via activation of C(sp2)?H bonds. The reaction proceeds using the easily accessible catalyst PdCl2, with Li2CO3 as inexpensive base and CuBr as additive, and tolerates a wide variety of substituents on both reaction partners.

Installation of protected ammonia equivalents onto aromatic & heteroaromatic rings in water enabled by micellar catalysis

A single set of conditions consisting of a palladium catalyst, a commercially available ligand, and a base, allow for several types of C-N bond constructions to be conducted in water with the aid of a commercially available "designer" surfactant (TPGS-750-M). Products containing a protected NH2 group in the form of a carbamate, sulfonamide, or urea can be fashioned starting with aryl or heteroaryl bromides, iodides, and in some cases, chlorides, as substrates. Reaction temperatures are in the range of room temperature to, at most, 50 °C, and result in essentially full conversion and good isolated yields.

HYDRAZONE DERIVATIVE

A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof

Copper-catalyzed cross-coupling of sulfonamides with aryl iodides and bromides facilitated by amino acid ligands

A highly general, convenient, and inexpensive catalyst system was developed for the N-arylation of sulfonamides with aryl iodides or bromides by using 5-20 mol % of CuI as catalyst, 20 mol % of N-methylglycine (for aryl iodides) or N,N-dimethylglycine (for aryl bromides) as ligand, and K3PO 4 as base.

HYDROXAMIC ACIDS USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS

This invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders.