7151-77-1

Basic information

• Product Name: ethyl 4-methanesulfonamidobenzoate
• Synonyms: ethyl 4-methanesulfonamidobenzoate;Ethyl 4-(MethylsulfonaMido)benzoate
• CAS NO: 7151-77-1
• Molecular Formula: C₁₀H₁₃NO₄S
• Molecular Weight: 243.28
• Mol File: 7151-77-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 375.6°Cat760mmHg
• Flash Point: 180.9°C
• Appearance: /
• Density: 1.319g/cm³
• Vapor Pressure: 7.72E-06mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: ethyl 4-methanesulfonamidobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-methanesulfonamidobenzoate(7151-77-1)
• EPA Substance Registry System: ethyl 4-methanesulfonamidobenzoate(7151-77-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 7151-77-1(Hazardous Substances Data)

Usage

General Description

Ethyl 4-methanesulfonamidobenzoate, also known as ethyl methanesulfonamidobenzoate, is a chemical compound with the formula C10H13NO3S. It is commonly used as an intermediate in the synthesis of pharmaceuticals, particularly in the production of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen. Ethyl 4-methanesulfonamidobenzoate has analgesic, anti-inflammatory, and antipyretic properties, making it a valuable component in the pharmaceutical industry. It is a white crystalline solid that is soluble in organic solvents and has a melting point of around 120°C. ethyl 4-methanesulfonamidobenzoate is also used in research laboratories for various chemical and biological studies.

InChI:InChI=1/C10H13NO4S/c1-3-15-10(12)8-4-6-9(7-5-8)11-16(2,13)14/h4-7,11H,3H2,1-2H3

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 94-09-7 p-aminoethylbenzoate 
• 3144-09-0 methanesulfonamide 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 

Downstream Products

• 183430-84-4 ethyl 3-nitro-4-[(methylsulfonyl)amino]benzoate 
• 774238-85-6 N-[4-(hydroxymethyl)phenyl]methanesulfonamide 
• 7151-76-0 4-(methylsulfonamido)benzoic acid 
• 183430-85-5 ethyl 3-amino-4-[(methylsulfonyl)amino]benzoate 

Relevant articles and documents

ORGANIC REACTIONS CARRIED OUT IN AQUEOUS SOLUTION IN THE PRESENCE OF A HYDROXYALKYL(ALKYL)CELLULOSE OR AN ALKYLCELLULOSE

The present invention relates to a method of carrying out an organic reaction in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose.

Palladium-Catalyzed cascade sp2 c?H bond functionalizations allowing one-Pot access to 4?Aryl-1,2,3,4-tetrahydroquinolines from n?Allyl?N?arylsulfonamides

We have developed a palladium-catalyzed cascade reaction allowing an efficient synthesis of 4-aryl-1,2,3,4-tetrahydroquinolines from N-allyl-N-arylsulfonamides and benzenesulfonyl chlorides. In this transformation, two C(sp2)?C(sp3) bonds were formed via activation of C(sp2)?H bonds. The reaction proceeds using the easily accessible catalyst PdCl2, with Li2CO3 as inexpensive base and CuBr as additive, and tolerates a wide variety of substituents on both reaction partners.

HYDRAZONE DERIVATIVE

A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof