71532-25-7Relevant academic research and scientific papers
All-Carbon Quaternary Stereocenters α to Azaarenes via Radical-Based Asymmetric Olefin Difunctionalization
Yin, Yanli,Li, Yunqiang,Gon?alves, Théo P.,Zhan, Qiangqiang,Wang, Guanghui,Zhao, Xiaowei,Qiao, Baokun,Huang, Kuo-Wei,Jiang, Zhiyong
, p. 19451 - 19456 (2020)
A radical-based asymmetric olefin difunctionalization strategy for rapidly forging all-carbon quaternary stereocenters α to diverse azaarenes is reported. Under cooperative photoredox and chiral Br?nsted acid catalysis, cyclopropylamines with α-branched 2-vinylazaarenes can undergo a sequential two-step radical process, furnishing various valuable chiral azaarene-substituted cyclopentanes. The use of the rigid and confined C2-symmetric imidodiphosphoric acid catalysts achieves high enantio- and diastereo-selectivities for these asymmetric [3 + 2] cycloadditions.
