71616-34-7Relevant academic research and scientific papers
Minimizing Aryloxy Elimination in RhI-Catalyzed Asymmetric Hydrogenation of β-Aryloxyacrylic Acids using a Mixed-Ligand Strategy
Li, Yang,Wang, Zheng,Ding, Kuiling
, p. 16387 - 16390 (2015/11/09)
The first example of efficient asymmetric hydrogenation of challenging β-aryloxyacrylic acids was realized using a RhI-complex based on the heterocombination of a readily available chiral monodentate secondary phosphine oxide (SPO) and an achiral monodentate phosphine ligand as the catalyst. Excellent enantioselectivities (92->99% ee) were achieved for a wide variety of chiral β-aryloxypropionic acids with minor aryloxy elimination in most cases. The resultant products were readily transformed into biologically active compounds through simple synthetic manipulations.
Electrochemical reduction of a bromo propargyloxy ester at silver cathodes in dimethylformamide
Henderson, Robert J.,Buehler, Nathan R.,Pasciak, Erick M.,Mubarak, Mohammad S.,Peters, Dennis G.
, p. G128 - G132 (2015/03/14)
Cyclic voltammograms for the reduction of ethyl 2-bromo-3-(3',4'-dimethoxyphenyl)-3-(propargyloxy)propanoate (1) at a silver cathode in dimethylformamide (DMF) containing 0.10 M tetraethylammonium tetrafluoroborate (TEABF4) exhibit several cathodic peaks,
CuII-exchanged montmorillonite K10 clay-catalyzed direct carboxylation of terminal alkynes with carbon dioxide
Aher, Ravindra D.,Gade, Madhuri H.,Reddy, R. Santhosh,Sudalai, Arumugam
, p. 1325 - 1329,5 (2020/08/31)
A new, simple and straight-forward protocol for direct carboxylation of terminal alkynes has been developed using CuII-montmorillonite K10 clay as a heterogeneous catalyst and CO2 as the C1 carbon feedstock. Also coupling of terminal alkynes with CO2 (1 atm) in the presence of alkyl halides has been achieved under the same reaction conditions, thereby providing access to a variety of functionalized alkyl-2-alkynoates in high yields.
11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents
Feng, Wei,Satyanarayana, Mavurapu,Tsai, Yuan-Chin,Liu, Angela A.,Liu, Leroy F.,LaVoie, Edmond J.
, p. 8598 - 8606 (2008/12/23)
Several 11-substituted benzo[i]phenanthridine derivatives were synthesized, and their TOP1-targeting activity and cytotoxicity were assessed. Comparative data indicate that TOP1-targeting was often the primary molecular target associated with their cytoto
