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Relevant academic research and scientific papers

2-Phenyl-1H-benzimidazole derivative and its application

The present invention belongs to the field of organic chemistry technology, specifically relates to a 2-phenyl-1H- benzimidazole derivative and its applications, the general structural formula as shown in formula (I): wherein R1, R2, R3, R4 are independently selected from hydrogen, halogen, hydroxyl, nitro or alkoxy; R5, R6, R7 Independently selected from hydrogen, hydroxyl or halogen, respectively; the small molecules of the present invention have a significant binding effect with the FTO protein, inhibiting the activity of FTO demethylase, showing good inhibitory activity on leukemia cells and inhibiting the function of renal transparent cell carcinoma.

Method for catalytically synthesizing benzimidazole compound by organic protonic acid under condition of no solvent

The invention discloses a method for catalytically synthesizing a benzimidazole compound by organic protonic acid under the condition of no solvent. According to the method provided by the invention,high efficiency catalysis is carried out to rapidly prep

HETERO-CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME

The present invention provides a hetero-cyclic compound capable of greatly improving lifespan, efficiency, electrochemical stability, and thermal stability of an organic light emitting device, and an organic light emitting device where the hetero-cyclic compound is contained in the organic compound layer. The hetero-cyclic compound is represented by chemical formula 1.COPYRIGHT KIPO 2017

Denitrogenative Imidoyl Radical Cyclization: Synthesis of 2-Substituted Benzoimidazoles from 1-Azido-2-isocyanoarenes

A novel access to 2-substituted benzoimidazoles, through unprecedented denitrogenative imidoyl radical cyclization of 1-azido-2-isocyanoarenes, has been developed. This tandem radical process was initiated by adding a C- or P-centered radical to isocyanide, followed by cycloaddition of the imidoyl radical to the azido group. Then, nitrogen loss and hydrogen abstraction of the resulting aminyl radical from surroundings delivered 2-substituted benzoimidazoles. Carbon radicals generated from another annulation process could also be applied, furnishing various heterocycle linked benzoimidazole derivatives.

Decarboxylative Coupling of α-Keto Acids with ortho-Phenylenediamines Promoted by an Electrochemical Method in Aqueous Media

An electrochemical method for the decarboxylative coupling of α-keto acids with ortho-phenylenediamines was developed. The reaction proceeded smoothly in aqueous solution under air and metal catalyst-free conditions to afford 2-substituted benzimidazoles in good yields. Benzothiazoles could also be synthesized by this protocol. (Figure presented.) .

Electrochemical Synthesis of Benzazoles from Alcohols and o-Substituted Anilines with a Catalytic Amount of CoII Salt

An electrochemical synthesis of benzazoles directly from alcohols and o-substituted anilines has been developed. The reaction conditions have been optimized by varying the composition of the electrolyte and the metal salt used as catalyst. The cyclization proceeds smoothly with a catalytic amount of a cobalt salt under air at room temperature to afford 2-substituted benzimidazoles, benzothiazoles, and benzoxazoles in good to excellent yields with a wide substrate scope.

Mesoporous Titania-Iron(III) Oxide with Nanoscale Porosity and High Catalytic Activity for the Synthesis of β-Amino Alcohols and Benzimidazole Derivatives

A mesoporous TiO2-Fe2O3 mixed oxide material (MTF-1E) with nanoscale porosity and a high BET surface area was synthesized using sodium dodecyl sulfate (SDS) as a structure-directing agent. The material was characterized by

An electroluminescent compound and an electroluminescent device comprising the same

The present invention relates to an organic light emitting compound applied to an organic light emitting device. The organic light emitting compound: is represented by chemical formula 1; includes one or more substituted bodies represented by structural formula 1 or structural formula 2; and is capable of realizing an organic light emitting device having excellent luminous properties such as driving voltage, luminance, a long life and the like in the case of being applied as a phosphorescent host compound in a hole transporting functional layer or an emissive layer.COPYRIGHT KIPO 2016

Unexpected behavior of imines derived from trifluoromethylaryl ketones under basic conditions: Convenient synthesis of 2-arylbenzimidazoles and 2-arylbenzoxazoles.

Imines derived form trifluoromethylaryl ketones, ortho-phenylenediamines or ortho-aminophenols undergo intramolecular cyclization with the elimination of the CF3 group under a variety of basic conditions to afford 2-arylbenzimidazoles and 2-aryloxazoles in good to excellent yields.

Syntheses of condensed imidazoles by lead tetraacetate oxidation of amidines

2-Phenylbenzimidazoles, 2-benzylbenzimidazoles, 2-phenyl-1H-naphtholimidazole, and 2-benzyl-1H-naphtholimidazole have been synthesized in excellent yields (77-98percent) by lead tetraacetate oxidation of suitable N-arylbenzimides, N-arylphenylacetamidines, N-α-naphthylbenzimidine, and N-α-naphthylphenylacetamidine respectively.The mechanism of nitrene insertation and intramolecular competitive nitrene insertation leading to these heterocycles has also been discussed.