716358-36-0

Usage

Uses

Used in Organic Synthesis:
(1-benzoyl-4-phenylpiperidine-4-yl)acetaldehyde is used as a key intermediate in the synthesis of various organic compounds due to its reactive aldehyde group and the presence of multiple functional groups that can participate in a range of chemical reactions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (1-benzoyl-4-phenylpiperidine-4-yl)acetaldehyde is used as a building block for the development of new pharmaceuticals, leveraging the bioactivity often associated with benzoyl and piperidine-containing molecules.
Further research and characterization are essential to explore the full potential of (1-benzoyl-4-phenylpiperidine-4-yl)acetaldehyde and to understand its properties and possible applications more comprehensively.

Upstream product

• 98-88-4 benzoyl chloride 
• 716358-34-8 tert-butyl 4-[(E/Z)-2-methoxyethenyl]-4phenylpiperidine-1-carboxylate 

Relevant academic research and scientific papers

Discovery of bioavailable 4,4-disubstituted piperidines as potent ligands of the chemokine receptor 5 and inhibitors of the human immunodeficiency virus-1

We describe robust chemical approaches toward putative CCR5 scaffolds designed in our laboratories. Evaluation of analogues in the 125I-[MIP-1β] binding and Ba-L-HOS antiviral assays resulted in the discovery of 64 and 68 in the 4,4-disubstitited piperidine class H, both potent CCR5 ligands (pIC50 = 8.30 and 9.00, respectively) and HIV-1 inhibitors (pIC50 = 7.80 and 7.84, respectively, in Ba-L-HOS assay). In addition, 64 and 68 were bioavailable in rodents, establishing them as lead molecules for further optimization toward CCR5 clinical candidates.

CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS

The present invention relates to compounds of formula (I) or pharmaceutically acceptable derivatives thereof, useful in the treatment or prophylaxis of CCR5-related diseases and disorders, for example, in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).