716379-95-2Relevant academic research and scientific papers
Synthesis and biological evaluation of oxindoles and benzimidazolinones derivatives
Messaoudi, Samir,Sancelme, Martine,Polard-Housset, Valerie,Aboab, Bettina,Moreau, Pascale,Prudhomme, Michelle
, p. 453 - 458 (2004)
The synthesis of new oxindoles and benzimidazolinones derivatives bearing a sugar residue on the aromatic nitrogen is described. The presence of the glycoside moiety should enhance the solubility of these heterocyclic compounds and/or improve the interact
Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives
Sassatelli, Mathieu,Bouchikhi, Fadoua,Messaoudi, Samir,Anizon, Fabrice,Debiton, Eric,Barthomeuf, Chantal,Prudhomme, Michelle,Moreau, Pascale
, p. 88 - 100 (2007/10/03)
In the course of structure-activity relationship studies, diversely substituted 1-(β-D-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.
Synthesis of glycosyl-isoindigo derivatives
Sassatelli, Mathieu,Saab, Elias,Anizon, Fabrice,Prudhomme, Michelle,Moreau, Pascale
, p. 4827 - 4830 (2007/10/03)
The synthesis of 1-(β-D-glucopyranosyl)-isoindigo from commercially available indoline is described. The synthetic pathway used allowed the substitution of the aromatic moiety by either electron donor or acceptor substituents.
