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1-(2,3,4,6-tetra-O-benzyl-1-deoxy-β-D-glucopyranos-1-yl)-1H-indole is a complex organic compound that features a 1H-indole moiety, which is a bicyclic aromatic system consisting of a benzene ring fused to a pyrrole. 1-(2,3,4,6-tetra-O-benzyl-1-deoxy-β-D-glucopyranos-1-yl)-1H-indole is characterized by a tetra-O-benzyl-1-deoxy-β-D-glucopyranosyl group attached to the indole. The term "tetra-O-benzyl" indicates that four hydroxyl groups of the glucopyranosyl moiety are protected by benzyl groups, which are aromatic rings that shield the hydroxyl groups and prevent unwanted reactions. The "1-deoxy" part of the name signifies the absence of an oxygen atom at the first carbon position of the glucopyranosyl ring, which is typically found in sugars. 1-(2,3,4,6-tetra-O-benzyl-1-deoxy-β-D-glucopyranos-1-yl)-1H-indole is of interest in organic chemistry and may be used in the synthesis of more complex molecules, particularly in the field of carbohydrate chemistry and medicinal chemistry, where such protected sugar derivatives can be employed as building blocks for the development of new drugs or as intermediates in the synthesis of biologically active compounds.

4196-37-6

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4196-37-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4196-37-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,9 and 6 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4196-37:
(6*4)+(5*1)+(4*9)+(3*6)+(2*3)+(1*7)=96
96 % 10 = 6
So 4196-37-6 is a valid CAS Registry Number.

4196-37-6Relevant academic research and scientific papers

Synthesis of glycosyl-isoindigo derivatives

Sassatelli, Mathieu,Saab, Elias,Anizon, Fabrice,Prudhomme, Michelle,Moreau, Pascale

, p. 4827 - 4830 (2004)

The synthesis of 1-(β-D-glucopyranosyl)-isoindigo from commercially available indoline is described. The synthetic pathway used allowed the substitution of the aromatic moiety by either electron donor or acceptor substituents.

Synthesis and antiproliferative evaluation of glucosylated pyrazole analogs of K252c

Douara, Bachir,Esvan, Yannick J.,Pereira, Elisabeth,Giraud, Francis,Volodina, Yulia L.,Kaluzhny, Dmitry N.,Shtil, Alexander A.,Anizon, Fabrice,Moreau, Pascale

, p. 892 - 901 (2018/01/27)

Pyrazole analogs of the staurosporine aglycon K252c were recently described as potent inhibitors of the three Pim protein kinase isoforms. To evaluate the impact of the introduction of a sugar moiety on the biological activities of this heterocyclic scaffold, four new glucosylated pyrazole analogs of K252c were synthesized. Their biological evaluation demonstrated that most active compounds 11 and 19 substituted by a β-D-glucosyl moiety at N12 or N13 positions exhibited antiproliferative activities toward HCT116 cells.

Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives

Sassatelli, Mathieu,Bouchikhi, Fadoua,Messaoudi, Samir,Anizon, Fabrice,Debiton, Eric,Barthomeuf, Chantal,Prudhomme, Michelle,Moreau, Pascale

, p. 88 - 100 (2007/10/03)

In the course of structure-activity relationship studies, diversely substituted 1-(β-D-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.

Synthesis and biological evaluation of oxindoles and benzimidazolinones derivatives

Messaoudi, Samir,Sancelme, Martine,Polard-Housset, Valerie,Aboab, Bettina,Moreau, Pascale,Prudhomme, Michelle

, p. 453 - 458 (2007/10/03)

The synthesis of new oxindoles and benzimidazolinones derivatives bearing a sugar residue on the aromatic nitrogen is described. The presence of the glycoside moiety should enhance the solubility of these heterocyclic compounds and/or improve the interact

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