71687-14-4

Upstream product

• 2028-74-2 p-chlorobenzenediazonium chloride 
• 7153-90-4 3-thiocyanatopentane-2,4-dione 
• 18247-78-4 2-oxo-N-(4-chlorophenyl)propanehydrazonoyl chloride 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 77722-47-5 5-acetyl-3-(4-chlorophenyl)-2-benzoylimino-3H-[1,3,4]thiadiazole 
• 122773-44-8 1-[5-Acetyl-3-(4-chloro-phenyl)-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-3-phenyl-thiourea 
• 122773-40-4 3-[5-Acetyl-3-(4-chloro-phenyl)-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-pentane-2,4-dione 
• 122773-39-1 2-[5-Acetyl-3-(4-chloro-phenyl)-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-1-phenyl-ethanone 
• 122773-43-7 1-[5-Acetyl-3-(4-chloro-phenyl)-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-3-benzoyl-thiourea 
• 122773-42-6 1-Acetyl-3-[5-acetyl-3-(4-chloro-phenyl)-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-thiourea 
• 122773-41-5 2-[5-Acetyl-3-(4-chloro-phenyl)-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-3-oxo-butyric acid ethyl ester 
• 77729-02-3 C₁₀H₇ClN₄O₂S 
• 77722-32-8 5-acetyl-3-(4-chlorophenyl)-1,3,4-thiadiazol-2(3H)-one 

Relevant academic research and scientific papers

Investigation of the inhibition efficiencies of novel synthesized cobalt complexes of 1,3,4-thiadiazolethiosemicarbazone derivatives for the acidic corrosion of carbon steel

Two novel thiosemicarbazone linked with 1,3,4-thiadiazole ligands were synthesized through the condensation reaction of the acetyl group at position 5 of 1,3,4-thiadiazole derivatives with thiosemicarbazide in acidic ethanol solution in addition to their

Reaction of Hydrazidoyl Halides with Thiocyanate Anion: Synthesis of Thiadiazolines and Thiadiazoloquinazoline

Hydrazidoyl chlorides (1a-d) react with potassium thiocyanate to give 5-imino-Δ2-1,3,4-thiadiazoline derivatives (4a-d).The corresponding N-acetyl-, N-benzoyl- and N-ethoxycarbonyl-thiadiazolines (5, 6 and 7) have been obtained via 1,3-dipolar cycloaddition of 1d to acetyl isothiocyanate, benzoyl isothiocyanate and ethoxycarbonyl isothiocyanate or via acylation reaction of compound 4d with acetyl chloride, benzoyl chloride and ethyl chloroformate.Compound 1e, however, on reaction with potassium thiocyanate furnishes directly the thiadiazoloquinazoline (8).Condensation of 4a with α-halogenketones and isothiocyanates gives N-alkylderivatives (9-11) and thioureas (12-14) respectively.Compound 4c on treatment with nitrous acid followed by reduction gives hydrazine derivative (16) via the intermediate 15.Bromination of 4b furnishes 17 which on reaction with cyanide ion furnishes the corresponding cyanoacetyl derivative (18).

Synthesis of Heterocycles. Part II. New Routes to Acetylthiadiazolines and Alkylazothiazoles

Methylglyoxalyl chloride arylhydrazones (III) react with an ethanolic solution of thiourea to give 2-amino-4-methyl-5-arylazothiazoles (XII) instead of the expected 2-acetyl-4-aryl-5-imino-Δ2-1,3,4-thiadiazolines (V) which were obtained from II