71687-76-8

Upstream product

• 98-80-6 phenylboronic acid 
• 753451-40-0 N-benzyl-N-(2-iodophenyl)propiolamide 
• 7135-32-2 1-benzylindolin-2-one 
• 100-46-9 benzylamine 
• 1217-89-6 1-benzylisatin 
• 103-80-0 phenylacetyl chloride 
• 909297-33-2 (E)-2-(((2-styrylphenyl)amino)methyl)phenol 
• 201230-82-2 carbon monoxide 
• 1100-88-5 benzyltriphenylphosphonium chloride 
• 87587-26-6 N-benzyl-2-(phenylethynyl)aniline 
• 779335-44-3 [(benzyl-phenyl-carbamoyl)-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-methyl]-phosphonic acid diethyl ester 
• 779335-37-4 [(benzyl-phenyl-carbamoyl)-methyl]-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis of (E)-3-Alkylideneindolin-2-ones by an Iron-Catalyzed Aerobic Oxidative Condensation of Csp3–H Bonds of Oxindoles and Benzylamines

A novel synthetic route for the construction of (E)-3-alkylideneindolin-2-ones through iron-catalyzed aerobic oxidative condensation of oxindoles with benzylamines has been developed. This oxidative reaction involves a sequence of C–H activation, amine self-condensation, nucleophilic addition, and C–C double bond formation. The synthetic importance of this protocol has been demonstrated by preparing tyrosine kinase inhibitors, anticonvulsant and antitumor agents, and other valuable 3-alkylideneindolin-2-one derivatives. Key intermediates are isolated and a plausible mechanistic pathway for the reaction has been discussed.

Copper-catalyzed hydroboration of alkenyl oxindoles

Herein we describe the NHC-Cu(I)-catalyzed hydroboration of alkenyl oxindoles. The corresponding boronates were obtained in good yields, under operationally simple and environmentally friendly conditions, using ethanol as the solvent. Our studies revealed that water-based systems were not very effective. Furthermore, the obtained products are amenable to further elaboration and can be useful to the synthesis of a broader range of oxindole-containing molecules with biological relevance.

Room-temperature palladium-catalyzed intramolecular oxidative aminocarbonylation of vinylic C(sp2)-H bonds with amines and CO

A new, mild route to access 3-methyleneindolin-2-ones is presented that proceeds through a room-temperature, palladium-catalyzed intramolecular oxidative aminocarbonylation of alkenes with amines and CO. This method represents a new aminocarbonylation str

Room-Temperature Palladium-Catalyzed Intramolecular Oxidative Aminocarbonylation of Vinylic C(sp2)-H Bonds with Amines and CO

A new, mild route to access 3-methyleneindolin-2-ones is presented that proceeds through a room-temperature, palladium-catalyzed intramolecular oxidative aminocarbonylation of alkenes with amines and CO. This method represents a new aminocarbonylation str

Diastereoselective access to tri-and pentacyclic spiro-γ-lactam- oxindole cores through a tandem aza-michael initiated ring closure sequence

Herein, we present a new development of the previously described aza-Michael-initiated ring closure (MIRC) process to access spirooxindole cores. The key spiro-cyclization step between various α-bromoacetamides and methyleneindolinones was efficient and tolerant of a wide range of functional groups. Yields and diastereoselectivities for the spirocyclization were usually high and furnished original spiro[oxindole-3,3′-γ-lactam] derivatives. The utility of these novel building blocks for the preparation of more sophisticated derivatives was demonstrated by the preparation of four pentacyclic spirooxindoles.

Palladium-catalyzed intramolecular 5-exo-dig hydroarylations of N-arylpropiolamides: Thermodynamics-controlled stereoselective synthesis of 3-methyleneoxindoles

(Chemical Equation Presented) Palladium-catalyzed intramolecular hydroarylation of N-arylpropiolamides has been developed for the stereoselective synthesis of 3-(monosubstituted methylene)oxindoles. In the presence of Pd(OAc)2 and dppf, a varie

Heterobimetallic cobalt/rhodium nanoparticle-catalyzed carbonylative cycloaddition of 2-alkynylanilines to oxindoles

(Chemical Equation Presented) The cobalt-rhodium heterobimetallic nanoparticle-catalyzed synthesis of oxindoles from 2-alkynylanilines in the presence of carbon monoxide is described.

Stereoselective synthesis of 3-alkylideneoxindoles using tandem indium-mediated carbometallation and palladium-catalyzed cross-coupling reactions

The first efficient methods for the stereoselective synthesis of various (E)-, (Z)-, and disubstituted 3-alkylideneoxindoles via radical cyclization reactions were investigated using tandem indium-mediated carbometallation and palladium-catalyzed cross-co

Stereoselective synthesis of 3-alkylideneoxindoles via palladium-catalyzed domino reactions

We have developed efficient catalytic methods for the stereoselective and diversity synthesis of various (E)-, (Z)-, and disubstituted 3-alkylideneoxindoles and 3-alkylidene-benzofuran-2-ones via palladium-catalyzed Heck/Suzuki-Miyaura, Heck/Heck, and Hec

Stereoselective synthesis of 3-alkylideneoxindoles using tandem in-mediated carbometalation and Pd-catalyzed cross-coupling reaction

Efficient methods for stereoselective synthesis of various (E)-, (Z)-, and disubstituted 3-alkylideneoxindoles were investigated using tandem In-mediated carbometalation and ligandless Pd-catalyzed coupling reaction.