717132-77-9Relevant academic research and scientific papers
Design and synthesis of bridged γ-lactams as analogues of β-lactam antibiotics
Aszodi, Jozsef,Rowlands, David A.,Mauvais, Pascale,Collette, Pascal,Bonnefoy, Alain,Lampilas, Maxime
, p. 2489 - 2492 (2004)
Anti-Bredt bridged bicyclo[3.2.1] γ-lactams were designed as inhibitors of penicillin binding proteins (PBPs). The compounds were prepared by a carbenoid insertion into a lactam N-H bond. Their weak antibacterial activity could either be explained by a poor chemical stability or by unfavorable steric interactions of the methylene bridge of the γ-lactam with the targeted enzymes.
