71785-49-4 Usage
Uses
Used in Organic Synthesis:
5-BROMO-6-NITRO-1H-INDAZOLE is used as a building block for the synthesis of various drug molecules and biologically active compounds. Its unique structure with both bromine and nitro groups enables further modification and functionalization, leading to the creation of new compounds with potential therapeutic applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-BROMO-6-NITRO-1H-INDAZOLE serves as a key intermediate in the development of novel drug candidates. Its chemical properties allow for the exploration of new chemical spaces and the optimization of drug-like properties, contributing to the discovery of innovative therapeutic agents.
Used as a Reagent in Chemical Reactions:
5-BROMO-6-NITRO-1H-INDAZOLE is utilized as a reagent in various chemical reactions, such as aromatic substitutions and palladium-catalyzed cross-coupling reactions. Its reactivity and functional groups facilitate the formation of new chemical bonds and the synthesis of complex molecular structures, expanding the scope of chemical research and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 71785-49-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,7,8 and 5 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 71785-49:
(7*7)+(6*1)+(5*7)+(4*8)+(3*5)+(2*4)+(1*9)=154
154 % 10 = 4
So 71785-49-4 is a valid CAS Registry Number.
71785-49-4Relevant academic research and scientific papers
Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt
Zhu, Gui-Dong,Gong, Jianchun,Gandhi, Viraj B.,Woods, Keith,Luo, Yan,Liu, Xuesong,Guan, Ran,Klinghofer, Vered,Johnson, Eric F.,Stoll, Vincent S.,Mamo, Mulugeta,Li, Qun,Rosenberg, Saul H.,Giranda, Vincent L.
, p. 2441 - 2452 (2007/10/03)
Thr-211 is one of three different amino acid residues in the kinase domain of protein kinase B/Akt as compared to protein kinase A (PKA), a closely related analog in the same AGC family. In an attempt to improve the potency and selectivity of our indazole-pyridine series of Akt inhibitors over PKA, efforts have focused on the incorporation of a chemical functionality to interact with the hydroxy group of Thr-211. Several substituents including an oxygen anion, amino, and nitro groups have been introduced at the C-6 position of the indazole scaffold, leading to a significant drop in Akt potency. Incorporation of a nitrogen atom into the phenyl ring at the same position (i.e., 9f) maintained the Akt activity and, in some cases, improved the selectivity over PKA. The structure-activity relationships of the new pyridine-pyrazolopyridine series of Akt inhibitors and their structural features when bound to PKA are also discussed.
