71790-91-5Relevant academic research and scientific papers
New approach to the synthesis of Oligo(nucleoside methanephosphonate)s
Wo?niak, Lucyna,Pyzowski, Jaros?aw,Stec, Wojciech J.
, p. 879 - 881 (2007/10/03)
A new method of preparation of 5′-O-DMT-(N-protected) nucleoside 3′-O-(methanephosphonofluoridates) 2 and their phosphonylating properties toward alcohols, in particular the 5′-hydroxyl groups of nucleosides (or nucleotides), is presented. Preparation of dinucleoside (37prime;,5′)-methanephosphonates 3 in solution and solid-phase synthesis of Me-Oligo 6 demonstrate the potential use of 2 as monomers.
SYNTHESIS OF OLIGODEOXYNUCLEOTIDES AND OLIGODEOXYNUCLEOTIDE ANALOGS USING PHOSPHORAMIDITE INTERMEDIATES
Dorman, M.A.,Noble, S.A.,McBride, L.J.,Caruthers, M.H.
, p. 95 - 102 (2007/10/02)
The synthesis of two deoxyoligonucleotides, d(G-T-G-A-G-T-T-A-G-C-T-C-A-C) and d(G-T-G-A-G-C-T-A-A-C-T-C-A-C), corresponding to the DNA binding site for cyclic AMP receptor protein is reported.These syntheses have been completed in milligram quantities using a silica gel polymer support methodology and mononucleotide phosphoramidites.Procedures are also reported for synthesizing diastereoisomers of dinucleoside methylphosphonate 3'-phosphoramidites.
