71814-52-3

Upstream product

• 54289-76-8 3-acetyl-4-hydroxy-1-methyl-2(1H)-quinolone 
• 100-63-0 phenylhydrazine 
• 1046810-18-7 C₁₈H₁₆ClN₃O 
• 956111-57-2 3-acetyl-4-methoxy-1-methylquinolin-2(1H)-one 
• 59-88-1 phenylhydrazine hydrochloride 
• 685891-37-6 1-methyl-2-oxo-3-[1-(phenylhydrazono)ethyl]-1,2-dihydroquinolin-4-yl 4-methylbenzenesulfonate 
• 93873-16-6 4-hydroxy-1-methyl-3-[1-(2-phenylhydrazinylidene)ethyl]quinolin-2(1H)-one 
• 97789-05-4 1-phenyl-3-methyl-4,5-dihydro-1H-pyrazolo<4,5-c>quinolin-4-one 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Synthesis and antioxidant properties of some novel 1,3,4,2-oxadiazaphosphepino[6,7-c]quinolinones and pyrazolo[3,4:4′,3′]quinolino[5,1-c][1,4,2]oxazaphosphinine

A series of novel 1,3,4,2-oxadiazaphosphepino[6,7-c]quinolinones 3–5, 9, and 11 have been synthesized from treatment of 4-hydroxy-1-methyl-3-[1-(2-phenylhydrazinylidene)ethyl]quinolin-2(1H)-one (2) with some phosphorus sulfides, diethyl phosphite and phen

Unexpected synthesis of 3,5-dimethyl-1-phenyl-1,5-dihydro-4Hpyrazolo[ 4,3-c]quinolin-4-one by non-classical Pschorr reaction, endowed with binding affinity for the central benzodiazepine receptor

The reaction of the diazonium salt 12 derived from N-(2-aminophenyl)-N,3- dimethyl-1-phenyl- 1H-pyrazole-5-carboxamide with copper sulfate and sodium chloride in the presence of ascorbic acid afforded the unexpected products 3,5-dimethyl-1-phenyl-1,5-dihy

Object-oriented synthetic approach toward angular and linear fused pyrazoloquinolines of biological importance with InCl3 catalyst

A simple and short approach for the synthesis of pyrazolo[3,4-b]quinoline (3a-3p) and pyrazolo[4,3-c]quinoline (6a-6 h) using various Lewis acid catalysts was developed. InCl3 was found to be more effective in providing greater yield of product

Regioselective synthesis of 2,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-ones by the cyclization of 3-acyl-4-methoxy-1-methylquinolinones with hydrazines

Reaction of 3-acyl-4-methoxy-1-methylquinolinones 2 and 5 with hydrazines has been investigated under different experimental conditions. Compound 2 always gave rise selectively and exclusively to the regioisomeric 1,3-disubstituted- or 2,3-disubstituted-pyrazolo[4,3-c]quinolin-4(5H)one (compounds 3a,b or 4a,b, respectively), while reaction of 5 with N-methylhydrazine led to a mixture of pyrazoles 7a and 8a. With N-phenylhydrazine, compounds 7b or 8b were regioselectively obtained. Compound 8a could be selectively synthesized working in solventless conditions. Structural elucidation of all products was independently achieved by NMR spectroscopy.

Synthesis of pyrazolo[4,3-c]quinolin-4-ones and indolo[3,2-c]quinolin-6- ones by the photocyclization of N-aryl-o-chloroheteroarenecarboxamides

An efficient synthesis of pyrazolo[4,3-c]quinolin-4-ones and indolo[3,2-c]quinolin-6-ones has been achieved by the photocyclization of 5-chloro-N-phenyl-1H-pyrazole-4-carboxamides and 2-chloro-N-phenyl-1H-indole-3- carboxamides in acetone. Georg Thieme Ve

Ring closure reactions of 3-arylhydrazonoalkyl-quinolin-2-ones to 1-aryl-pyrazolo[4,3-c]quinolin-2-ones

4-Hydroxy-3-arylhydrazonoalkyl-2-quinolones 6 or reactive derivatives such as 3-arylhydrazonoalkyl-4-tosyloxy-2-quinolones 7 or 4-chloro-3- arylhydrazonoalkyl-2-quinolones 14, which are obtained via 3-acyl-4- hydroxyquinolones 4, 10 or 3-phenylaminomethylene-quinoline-2,4-diones 12, cyclize in excellent yields to 1-aryl-pyrazolo[4,3-c]quinolin-4-ones (11). The cyclization conditions were investigated by differential scanning calorimetry (DSC).

Pyrazoloquinolines. 2. Synthesis and Specific Inhibition of Benzodiazepine Receptor Binding

A series of 1-aryl-3,5-dimethyl-4,5-dihydro-1H-pyrazoloquinolin-4-ones (2a-e) and 1-aryl-3-methyl-1H-pyrazoloquinolines (3-7a-e) bearing different substituents at position 4 were prepared and tested for their ability to displace specific 3H