97789-05-4

Upstream product

• 378208-67-4 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid anilide 
• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 70254-43-2 4-Hydroxy-2-quinolone 
• 101569-81-7 4-hydroxy-3-[1-(phenylhydrazono)ethyl]-quinolin-2(1H)-one 
• 26138-64-7 4-hydroxy-3-acetyl-1H-quinoline-2-one 
• 100-63-0 phenylhydrazine 
• 529-23-7 o-aminobenzaldehyde 
• 89-25-8 edaravone 
• 100066-72-6 Ethyl 3-methyl-5-(2-nitrophenyl)-1-phenyl-pyrazole-4-carboxylate 
• 100066-73-7 5-Hydroxy-3-methyl-1-phenyl-pyrazolo<4,3-c>quinolin-4(5H)-one 

Downstream Products

• 71814-52-3 3,5-dimethyl-1-phenyl-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one 
• 98990-76-2 4-Chloro-3-methyl-1-phenyl-1H-pyrazolo[4,3-c]quinoline 
• 98990-91-1 3-Methyl-4-(4-methyl-piperazin-1-yl)-1-phenyl-1H-pyrazolo[4,3-c]quinoline 
• 98990-96-6 3-Methyl-4-morpholin-4-yl-1-phenyl-1H-pyrazolo[4,3-c]quinoline 
• 98990-86-4 4-Ethoxy-3-methyl-1-phenyl-1H-pyrazolo[4,3-c]quinoline 
• 98990-81-9 4-Methoxy-3-methyl-1-phenyl-1H-pyrazolo[4,3-c]quinoline 

Relevant academic research and scientific papers

Substituted quinolinones 27. Regioselective synthesis of pyrazolo-, oxazolo-, and triazepinoquinoline derivatives

Reactivity of 3-acetyl-4-(methylsulfanyl)quinolin-2(1H)-one towards 1,2- and/or 1,4-diazanucleophiles has been studied under different reaction conditions. Condensation of 3-acetyl-4-(methylsulfanyl)quinolin-2(1H)-one with hydrazine, phenylhydrazine, hydr

Synthesis of pyrazolo[4,3-c]quinolin-4-ones and indolo[3,2-c]quinolin-6- ones by the photocyclization of N-aryl-o-chloroheteroarenecarboxamides

An efficient synthesis of pyrazolo[4,3-c]quinolin-4-ones and indolo[3,2-c]quinolin-6-ones has been achieved by the photocyclization of 5-chloro-N-phenyl-1H-pyrazole-4-carboxamides and 2-chloro-N-phenyl-1H-indole-3- carboxamides in acetone. Georg Thieme Ve

1,2-Diaryl-1-ethanone and pyrazolo [4,3-c] quinoline-4-one as novel selective cyclooxygenase-2 inhibitors

Novel 1,2-diaryl-1-ethanone 1 and pyrazolo [4,3-c] quinoline-4-one 2, with pharmacophores different from the known COX inhibitors were identified as selective COX-2 inhibitors. The communication briefly describes SAR of both the series.

Ring closure reactions of 3-arylhydrazonoalkyl-quinolin-2-ones to 1-aryl-pyrazolo[4,3-c]quinolin-2-ones

4-Hydroxy-3-arylhydrazonoalkyl-2-quinolones 6 or reactive derivatives such as 3-arylhydrazonoalkyl-4-tosyloxy-2-quinolones 7 or 4-chloro-3- arylhydrazonoalkyl-2-quinolones 14, which are obtained via 3-acyl-4- hydroxyquinolones 4, 10 or 3-phenylaminomethylene-quinoline-2,4-diones 12, cyclize in excellent yields to 1-aryl-pyrazolo[4,3-c]quinolin-4-ones (11). The cyclization conditions were investigated by differential scanning calorimetry (DSC).