71834-43-0

Basic information

• Product Name: 4-(4-methylphenyl)-6-phenyl-3,4-dihydropyrimidine-2(1H)-thione
• Synonyms: 4-(4-methylphenyl)-6-phenyl-3,4-dihydropyrimidine-2(1H)-thione
• CAS NO: 71834-43-0
• Molecular Weight: 280.393
• Mol File: 71834-43-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-(4-methylphenyl)-6-phenyl-3,4-dihydropyrimidine-2(1H)-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methylphenyl)-6-phenyl-3,4-dihydropyrimidine-2(1H)-thione(71834-43-0)
• EPA Substance Registry System: 4-(4-methylphenyl)-6-phenyl-3,4-dihydropyrimidine-2(1H)-thione(71834-43-0)

Safety Data

• Hazardous Substances Data: 71834-43-0(Hazardous Substances Data)

Upstream product

• 4224-87-7 4-methyl-chalcone 
• 17356-08-0 thiourea 
• 16619-29-7 phenyl m-methylstyryl ketone 
• 104-87-0 4-methyl-benzaldehyde 
• 98-86-2 acetophenone 
• 98-88-4 benzoyl chloride 
• 622-97-9 1-ethenyl-4-methylbenzene 

Downstream Products

• 66443-34-3 4-phenyl-6-p-tolyl-1⁽³⁾H-pyrimidine-2-thione 

Relevant articles and documents

Synthesis, Molecular Docking and Biological Evaluation of Diaryl Pyrimidine Derivatives as Urease Inhibitors

Urease is a dinickel enzyme that is responsible for the hydrolysis of urea to ammonia and carbon dioxide. A series of bacteria like Helicobacter pylori produce urease in order to release ammonia via urea hydrolysis and survive in acidic environments. Urease inhibitors are often used as a part of the medical treatment of infections by ureolytic bacteria. In this work, a series of diaryl pyrimidine derivatives (compounds 6a–6i) have been synthesized as urease inhibitors, their inhibitory activities against Jack bean urease have been investigated in vitro, and the obtained values of IC50 showed potent urease inhibitory activity. Cytotoxic activity of the synthesized compounds was evaluated against four cell lines (HT-29, MCF-7, T47D, and NIH3T3). Many of the tested compounds did not show significant cytotoxicity, and compounds 6d, 6g, and 6i did not show any cytotoxic activity against these cell lines. Among these, compound 6d showed the most pronounced urease inhibitory activity (IC50 = 780 ± 50nM), being over 28-fold more potent than thiourea (IC50 = 22.01 ± 0.08 ìM) and 128-fold more potent than hydroxyurea (IC50 = 100.00 ± 0.08 ìM) as standard inhibitors, respectively. The results of molecular docking studies showed that compound 6b had the best binding energy and exhibited proper interaction with the active site of urease.

Visible Light-Promoted Friedel-Crafts-Type Chloroacylation of Alkenes to β-Chloroketones

The photoredox chloroacylation of alkenes has been developed as a substitute for the Friedel-Crafts acylation of alkenes to β-chloroketones. The direct generation of acyl radical species from acid chlorides under the photoredox conditions allows the formation of β-chloroketones without dehydrochlorination with the help of KHCO3. The synthetic utility of the current method is demonstrated in the one-pot synthesis of dihydroisoxazole, dihydropyrazole, and dihydropyrimidine-2-thione in 1 mmol scale.

Preparation of 4,6-Diaryl-3,4-dihydropyrimidine-2(1H)-thiones in an ionic liquid

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