71845-10-8 Usage
Structure
1H-pyrrole-2,4-dicarboxylic acid with a 3-(4-fluorophenyl) substituent The compound is based on a pyrrole ring system with two carboxylic acid groups at positions 2 and 4, and a 4-fluorophenyl group attached at position 3.
3. Dimethyl ester derivative The carboxylic acid groups in 1H-Pyrrole-2,4-dicarboxylic acid, 3-(4-fluorophenyl)-, dimethyl ester are esterified with methanol, resulting in two methyl ester groups.
Pharmaceutical research application
Building block for drug synthesis The compound is commonly used as a starting material or building block in the synthesis of potential drugs due to its diverse chemical reactivity and potential biological activity.
Organic chemistry application
Versatile intermediate 1H-Pyrrole-2,4-dicarboxylic acid, 3-(4-fluorophenyl)-, dimethyl ester is also utilized as a versatile intermediate in the synthesis of various organic compounds.
Importance in research
Potential applications in both pharmaceutical and organic chemistry The compound holds significant value in the fields of pharmaceutical and organic chemistry research due to its potential applications in drug development and synthesis of other organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 71845-10-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,8,4 and 5 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 71845-10:
(7*7)+(6*1)+(5*8)+(4*4)+(3*5)+(2*1)+(1*0)=128
128 % 10 = 8
So 71845-10-8 is a valid CAS Registry Number.
71845-10-8Relevant academic research and scientific papers
FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
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Paragraph 0683, (2017/08/01)
Provided herein are substituted fused quadracyclic compounds useful as inhibitors of MK2. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted fused quadracyclic compounds.
Oligosubstituted pyrroles directly from substituted methyl isocyanides and acetylenes
Lygin, Alexander V.,Larionov, Oleg V.,Korotkov, Vadim S.,De Meijere, Armin
supporting information; experimental part, p. 227 - 236 (2009/06/20)
The formal cycloaddition of α-metallated methyl isocyanides 1 onto the triple bond of electron-deficient acetylenes 2 represents a direct and convenient approach to oligosubstituted pyrroles 3. The scope and limitations of this reaction (24 examples, 2597 % yield) are reported along with an optimization of the reaction conditions and a rationalization of the mechanism. In addition, a related newly developed CuI-mediated synthesis of 2,3-disubstituted pyrroles by the reaction of copper acetylides derived from unactivated terminal alkynes with substituted methyl isocyanides is described (11 examples, 5-88% yield).
