71849-99-5Relevant articles and documents
Synthesis of 2-Aminocarboxylic Acids on the Basis of Metalated Lithium Acylates
Zorin,Lenkova,Khachaturyan,Zorin
, p. 1590 - 1594 (2018/11/10)
2-Aminocarboxylic acids have been synthesized through the reaction of lithium acylate α-carbanions with alkyl nitrites to form α-hydroxyiminoacylates, followed by reduction of the latter with tin chloride. The reactions of lithium acylate α-carbanions, ge
A convenient synthesis of N-boc-protected α-aminonitriles from α-amidosulfones
Banphavichit, Vorawit,Chaleawlertumpon, Saowaluk,Bhanthumnavin, Worawan,Vilaivan, Tirayut
, p. 3147 - 3160 (2007/10/03)
Synthesis of N-Boc-protected α-aminonitriles starting from N-Boc-protected α-aminosulfones is described. Treatment of the sulfone with two equivalents of potassium cyanide in 2-propanol or dichloromethane- H2O under phase transfer condition affords crystalline N-Boc-protected α-aminonitriles in good yield. Hydrolysis of the aminonitriles provides a convenient access to racemic α-amino acids.
A new synthesis of α-arylglycines from aryl boronic acids
Petasis, Nicos A.,Goodman, Andrew,Zavialov, Ilia A.
, p. 16463 - 16470 (2007/10/03)
Aryl and heteroaryl boronic acids react with the adducts of amines and glyoxylic acid to give the corresponding α-aryl and α-heteroaryl glycine derivatives. Several examples of this reaction with m- and p- substituted aryl boronic acids as well as 3-thienyl, 2-thienyl, 2- furyl, 2-benzo[b]furyl and 2-benzo[b]thienyl boronic acids are described.
