111652-10-9Relevant academic research and scientific papers
A novel, general route to the synthesis of carboxylic acid esters and thiolesters
Sucheta,Reddy,Ravi,Rama Rao
, p. 4415 - 4416 (1994)
Carboxylic acids were conveniently esterified with alcohols and thiols by the use of triphenylphosphine and N-bromo/Iodo succinimide to afford the corresponding esters and thiol esters.
Copper-catalyzed asymmetric N-H insertion reactions: Couplings of diazo compounds with carbamates to generate α-amino acids
Lee, Elaine C.,Fu, Gregory C.
, p. 12066 - 12067 (2008/03/27)
A Cu/chiral bipyridine catalyst has been developed for the asymmetric insertion of α-diazocarbonyl compounds into the N-H bonds of carbamates to generate an array of easily deprotected arylglycines in good ee. With respect to the reaction partners, as wel
A convenient synthesis of N-Boc-protected tert-butyl esters of phenylglycines from benzylamines
Kise, Naoki,Ozaki, Hiroshi,Terui, Hiroaki,Ohya, Kengo,Ueda, Nasuo
, p. 7637 - 7639 (2007/10/03)
The N,N-di-Boc-protected benzylamines undergo [1,2] Boc migration on treatment with KDA/t-BuOLi. By this reaction, the corresponding N-Boc-protected t-butyl esters of phenylglycines are obtained in high yields.
Synthesis of α-Amino Acids by Reaction of t-Butyl N-(t-Butoxycarbonyl)iminoacetate With C-Nucleophiles
Muenster, Peter,Steglich, Wolfgang
, p. 223 - 225 (2007/10/02)
The reaction of t-butyl N-(t-butoxycarbonyl)iminoacetate with Grignard reagents or enamines yields N-(t-butoxycarbonyl)amino acid t-butyl esters which can be easily converted into the free amino acids by treatment with acids.
