71862-02-7

Usage

InChI:InChI=1/C8H8ClNO/c1-6-7(9)3-2-4-8(6)10-5-11/h2-5H,1H3,(H,10,11)

Upstream product

• 87-60-5 3-chloro-2-methylbenzenamine 
• 122-51-0 orthoformic acid triethyl ester 
• 68-12-2 N,N-dimethyl-formamide 
• 64-18-6 formic acid 

Downstream Products

• 41456-52-4 3-chloro-2-methylbenzylamine 
• 1073265-77-6 N₃-(3-chloro-2-methylphenyl)-N₁-(4-chlorobenzyl)-4-methoxy-N₃-methylbenzene-1,3-disulfonamide 
• 1073265-76-5 5-bromo-N-(3-chloro-2-methylphenyl)-2-methoxy-N-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Copper-(II) Catalyzed N-Formylation and N-Acylation of Aromatic, Aliphatic, and Heterocyclic Amines and a Preventive Study in the C-N Cross Coupling of Amines with Aryl Halides

A Cu-(II) catalyzed N-formylation and N-acylation of amines with moderate to excellent yields, using N, N-dimethyl formamide (DMF) and N, N-dimethyl acetamide (DMA) as a formyl and acylating sources in the presence of 1,2,4-triazole is reported. This novel, highly efficient and simple protocol shows broad substrate scope for aliphatic, aromatic, and heterocyclic amines. In addition, the conditions to prevent N-formylation and N-acylation impurities in the C?N cross coupling of amines and aryl halides are described typically when DMF and DMA are used as solvents, with various catalysts, ligands, and bases.

Nickel-(II)-Catalyzed N-Formylation and N-Acylation of Amines

A highly efficient protocol of Ni(II) metal complex, [Ni(quin)2], catalyzing N-formylation and N-acylation of amines with moderate to excellent yields, using N,N-dimethylformamide and N,N-dimethylacetamide in the presence of imidazole, is described here. The protocol shows broad substrate scope for aliphatic, aromatic, and heterocyclic amines.

Co3O4 nanoparticles prepared by oxidative precipitation method: an efficient and reusable heterogeneous catalyst for N-formylation of amines

Abstract: N-formylation of different amines was carried out with formic acid in the presence of the Co3O4 nanoparticles as an efficient, stable heterogeneous catalyst to give the corresponding formamides under solvent-free conditions. This method has advantages over the reported methods such as high yields, mild conditions, easy work-up and short reaction times. The catalyst was characterized by different techniques such as XRD, SEM and FT-IR spectroscopy. Graphical Abstract: [Figure not available: see fulltext.]

Organic reactions in water: A practical and convenient method for the N-formylation of amines in water

A simple, efficient, scaleable process has been developed for the N-formylation amines in water. Treatment of amines with triethyl orthoformate in water at reflux under neutral conditions without any additives gives the corresponding N-formyl derivatives in good yields. Georg Thieme Verlag Stuttgart - New York.

DISULFONAMIDES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I), wherein Y1, Y2, Y3, Y4, T1, T2, W1, W2, R1 and R2 have meanings given in the description, and pharmac

Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.