7189-12-0

Usage

Type of compound

Ethyl ester derivative of 1,3,5-triphenylpyrazole-4-carboxylic acid, a pyrazole derivative

Common uses

Building block for the synthesis of pharmaceuticals and agrochemicals, reagent in the preparation of organic compounds with potential medicinal or industrial applications

Ester form

Easier to handle and store, allowing for easier handling in laboratory settings

Versatility

Range of potential applications in the field of organic chemistry.

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 588-64-7 benzaldehyde phenylhydrazone 
• 64-17-5 ethanol 
• 53685-84-0 1,3,5-triphenyl-1H-pyrazole-4-carboxylic acid 
• 3556-76-1 ethyl (2Z)-3-phenyl-3-(phenylamino)prop-2-enoate 
• 100-47-0 benzonitrile 
• 579-45-3 N-benzoyl-N-phenylhydrazine 
• 100-63-0 phenylhydrazine 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 

Relevant academic research and scientific papers

PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES

The invention describes a novel process for synthesizing pyrazoles by means of oxidative conversion of enamines with suitable N-containing carboxylic acid derivatives.

Efficient synthesis of pyrazoles: Oxidative C-C/N-N bond-formation cascade

Golden section: A novel synthetic strategy for the synthesis of tetrasubstituted pyrazoles is provided. In an efficient C-C/N-N bond-formation cascade, enamines and nitriles are oxidatively coupled to deliver pyrazoles in good yields (see scheme). The rea

The first chemoselective tandem acylation of the Blaise reaction intermediate: A novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles

The Blaise reaction intermediate, a zinc bromide complex of β-enamino ester, could be activated in situ by addition of a stoichiometric or catalytic amount of n-BuLi to allow chemoselective tandem C2-acylation providing α-acyl-β-enamino esters, which are

1,3-Dipolar Cycloaddition of Benzonitrilium N-Phenylimide with 4-Arylmethylidene-3-phenylisoxazol-5(4H)-ones

The title reaction, when carried out in benzene and in the presence of triethylamine, afforded 5-aryl-1,3-diphenylpyrazole-4-carboxylic acids 11 in 50-60percent yields.

Synthesis of 4-Acyl- and 4-Alkoxy-carbonylpyrazoles

N'-Aroyl- or N'-acetyl, N'-phenyl- or N'-methyl-hydrazino-derivatives (1) of 1,3-dicarbonyl compounds can be converted by mild base treatment into 5-aryl- or 5-methyl-, 1-phenyl- or 1-methylpyrazoles carrying an acyl or alkoxycarbonyl group at C-4.