7189-12-0

Basic information

• Product Name: 1H-Pyrazole-4-carboxylic acid, 1,3,5-triphenyl-, ethyl ester
• CAS NO: 7189-12-0
• Molecular Formula: C24H20N2O2
• Molecular Weight: 368.435
• Mol File: 7189-12-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4-carboxylic acid, 1,3,5-triphenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxylic acid, 1,3,5-triphenyl-, ethyl ester(7189-12-0)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxylic acid, 1,3,5-triphenyl-, ethyl ester(7189-12-0)

Safety Data

• Hazardous Substances Data: 7189-12-0(Hazardous Substances Data)

Usage

Type of compound

Ethyl ester derivative of 1,3,5-triphenylpyrazole-4-carboxylic acid, a pyrazole derivative

Common uses

Building block for the synthesis of pharmaceuticals and agrochemicals, reagent in the preparation of organic compounds with potential medicinal or industrial applications

Ester form

Easier to handle and store, allowing for easier handling in laboratory settings

Versatility

Range of potential applications in the field of organic chemistry.

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 588-64-7 benzaldehyde phenylhydrazone 
• 3556-76-1 ethyl (2Z)-3-phenyl-3-(phenylamino)prop-2-enoate 
• 100-47-0 benzonitrile 
• 100-63-0 phenylhydrazine 
• 64-17-5 ethanol 
• 53685-84-0 1,3,5-triphenyl-1H-pyrazole-4-carboxylic acid 
• 579-45-3 N-benzoyl-N-phenylhydrazine 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 

Relevant articles and documents

PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES

The invention describes a novel process for synthesizing pyrazoles by means of oxidative conversion of enamines with suitable N-containing carboxylic acid derivatives.

The first chemoselective tandem acylation of the Blaise reaction intermediate: A novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles

The Blaise reaction intermediate, a zinc bromide complex of β-enamino ester, could be activated in situ by addition of a stoichiometric or catalytic amount of n-BuLi to allow chemoselective tandem C2-acylation providing α-acyl-β-enamino esters, which are

Synthesis of 4-Acyl- and 4-Alkoxy-carbonylpyrazoles

N'-Aroyl- or N'-acetyl, N'-phenyl- or N'-methyl-hydrazino-derivatives (1) of 1,3-dicarbonyl compounds can be converted by mild base treatment into 5-aryl- or 5-methyl-, 1-phenyl- or 1-methylpyrazoles carrying an acyl or alkoxycarbonyl group at C-4.