719-31-3

Upstream product

• 520-43-4 2-hydroxy-4-methoxy-6-methyl-benzoic acid methyl ester 
• 3187-58-4 methyl orsellinate 
• 715-34-4 methyl 3,5-dichloro-2,4-dihydroxy-6-methylbenzoate 

Downstream Products

• 78135-49-6 2-Benzyloxy-3,5-dichloro-4-methoxy-6-methyl-benzoic acid methyl ester 
• 21669-34-1 2-benzyloxy-3,5-dichloro-4-methoxy-6-methylbenzoic acid 
• 69769-50-2 methyl 3-chloro-6-(3,5-dichloro-2-hydroxy-4-methoxy-6-methylphenoxy)-4-hydroxy-2-methylbenzoate 
• 78135-44-1 3,5-dichloro-2,4-dihydroxy-6-methylphenyl 4-chloro-5-hydroxy-3-methylphenyl ether 
• 69709-89-3 3,5,5'-trichloro-2,2',4'-trihydroxy-4-methoxy-6,6'-dimethylbenzophenone 
• 69709-92-8 3,5,5'-trichloro-2,2'-dihydroxy-4,4'-dimethoxy-6,6'-dimethylbenzophenone 
• 78135-52-1 methyl 3-chloro-6-(3,5-dichloro-2-hydroxy-4-methoxy-6-methylphenoxy)-4-methoxy-2-methylbenzoate 
• 78135-36-1 2,2',4'-tribenzyloxy-3,5,5'-trichloro-4-methoxy-6,6'-dimethylbenzophenone 

Relevant academic research and scientific papers

2,2,6,6-Tetramethylpiperidine-catalyzed, ortho-selective chlorination of phenols by sulfuryl chloride

2,2,6,6-Tetramethylpiperidine (TMP)-catalyzed (1- 10%) chlorinations of phenols by SO2Cl2 in aromatic solvents are more ortho selective than with primary and less hindered secondary amine catalysts. Ortho-selective chlorination is successful even with electron deficient phenols such as 2-hydroxybenzaldehyde and 2'- hydroxyacetophenone. Notably, ortho selectivity increases with the reaction temperature. On the other hand, tetraalkylammonium chloride-catalyzed chlorinations are moderately para selective.

Depsidone Synthesis. Part 16. Benzophenone-Grisa-3',5'-diene-2',3-dione-depsidone Interconversion: a New Theory of Depsidone Biosynthesis

The synthesis of a number of grisa-3',5'-diene-2',3-diones by oxidative coupling of substituted 2,2'-dihydroxy-4-methoxybenzophenones is described.The rearrangement of these grisadienediones to depsidones under basic, acidic, and thermal conditions is des