719304-25-3

Basic information

• Product Name: 3-(2-benzyloxynaphthalen-1-yl)-4-(pyrrolidin-1-yl)pyridine
• Synonyms: 3-(2-benzyloxynaphthalen-1-yl)-4-(pyrrolidin-1-yl)pyridine
• CAS NO: 719304-25-3
• Molecular Weight: 380.489
• Mol File: 719304-25-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-benzyloxynaphthalen-1-yl)-4-(pyrrolidin-1-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-benzyloxynaphthalen-1-yl)-4-(pyrrolidin-1-yl)pyridine(719304-25-3)
• EPA Substance Registry System: 3-(2-benzyloxynaphthalen-1-yl)-4-(pyrrolidin-1-yl)pyridine(719304-25-3)

Safety Data

• Hazardous Substances Data: 719304-25-3(Hazardous Substances Data)

Upstream product

• 13626-17-0 3,5-dibromo-4-chloro-pyridine 
• 219834-96-5 2-(phenylmethoxy)-1-naphthalene boronic acid 
• 719304-22-0 3,5-dibromo-4-(pyrrolidin-1-yl)-pyridine 

Downstream Products

• 719304-41-3 (+/-)-3-(2-phenylnaphthalen-1-yl)-4-(pyrrolidin-1-yl)pyridine 

Relevant articles and documents

New atropisomeric biaryl derivatives of 4-aminopyridine - Identification of an improved nucleophilic catalyst for asymmetric acylation of sec-alcohols

The synthesis, CSP-HPLC resolution, and absolute configuration assignment of a series of 4-dialkylaminopyridine-based atropisomeric biaryls are described. Screening of these enantiomerically pure catalysts, which differ only in the nature of the 4-dialkylamino substituent, for the kinetic resolution of 1-(1-naphthyl)ethanol reveals the importance of this group on the selectivity of catalysis. The di-n-butylamino derivative displays the most favourable catalytic profile. The utility of this catalyst for the kinetic resolution of a selection of sec-alcohols, including a precursor for the synthesis of the antidepressant fluoxetine hydrochloride (Prozac) are reported. The possible role of the dialkylamino group in chirality transfer is discussed.