219834-96-5Relevant articles and documents
Catalytic Enantioselective Synthesis of Axially Chiral Diarylmethylidene Indanones
Kumar, Prashant,Shirke, Rajendra P.,Yadav, Sonu,Ramasastry
, p. 4909 - 4914 (2021/06/30)
We describe the first atropselective Suzuki-Miyaura cross-coupling of β-keto enol triflates to access axially chiral (Z)-diarylmethylidene indanones (DAIs). The chemical, physical, and biological properties of DAIs are unknown, despite their being structurally similar to arylidene indanones, primarily due to the lack of racemic or chiral methods. Through this work, we demonstrate a general and efficient protocol for the racemic as well as the atropselective synthesis of (Z)-DAIs. An unusual intramolecular Morita-Baylis-Hillman reaction is utilized for the Z-selective synthesis of β-keto enol triflates.
Efficient synthesis of chiral 1,1′-binaphthalenes by the asymmetric suzuki-miyaura reaction: Dramatic synthetic improvement by simple purification of naphthylboronic acids
Genov, Miroslav,Almorin, Antonio,Espinet, Pablo
, p. 9346 - 9352 (2007/10/03)
Naphthylboronic acids prepared as reported in the literature are contaminated with HCl. A very simple purification prior to their use in Suzuki-Miyaura couplings has been found to be crucial, rendering efficient some reactions that had been reported in th
