71932-99-5Relevant articles and documents
A STEREOSPECIFIC SYNTHESIS OF CHIRAL 1,3-DISUBSTITUTED BROMOALLENES
Corey, E. J.,Boaz, Neil W.
, p. 3055 - 3058 (1984)
Optically active 1,3-disubstituted propargyl alcohols undergo SNi' rearrangements with thionyl bromide in the presence of propylene oxide to yield bromoallenes without loss of optical purity.
Total Synthesis and Antitrypanosomal Activity of Janadolide and Simplified Analogues
Chung, Jonathan H.,Corcilius, Leo,Geraghty, Kieran,Kaiser, Marcel,Payne, Richard J.,Tang, Arthur H.
supporting information, (2020/04/20)
Janadolide is a cyclic depsipeptide natural product isolated from the marine cyanobacterium Okeania sp. Herein, we describe the total synthesis of janadolide, along with eight simplified analogues, via an efficient solid-phase strategy. Crucial to the synthesis of the natural product was the construction of a key polyketide fragment via an enantioselective (-)-B-chlorodiisopinocampheylborane-mediated reduction and a B-alkyl Suzuki reaction. Janadolide and the simplified analogues exhibited antitrypanosomal activity against pathogenic Trypanosoma brucei rhodesiense and Trypanosoma cruzi parasites.
Synthesis of carbonyl and dicarbonyl compounds from organometallic reagents and N-imidazolium-N-methyl amides and bis-amides
De Las Heras, Maria A.,Vaquero, Juan J.,Garcia Navio, Jose L.,Alvarez-Builla, Julio
, p. 14297 - 14310 (2007/10/03)
A new method for the synthesis of selective acylating agents is described from the reaction of carboxylic acids with 3-methyl-1-methylamino-3H-imidazol-1-ium salts in the presence of appropriate coupling reagents. The amides and bis-amides thus prepared reacted selectively with organometallics to afford ketones and diketones and with DIBALH to give aldehydes and dialdehydes in high yields.
