71932-99-5Relevant academic research and scientific papers
A STEREOSPECIFIC SYNTHESIS OF CHIRAL 1,3-DISUBSTITUTED BROMOALLENES
Corey, E. J.,Boaz, Neil W.
, p. 3055 - 3058 (1984)
Optically active 1,3-disubstituted propargyl alcohols undergo SNi' rearrangements with thionyl bromide in the presence of propylene oxide to yield bromoallenes without loss of optical purity.
Studies on the Photochemical Reactions of α,β-Acetylenic Ketones with Tetramethylethylene
Saba, Shahrokh,Wolff, Steven,Schroeder, Clemens,Margaretha, Paul,Agosta, William C.
, p. 6902 - 6907 (1983)
With exclusion of acid, photolysis of mixtures of 1 and 2 in benzene yields 7a and 8a, which rearrange readily to 3, the previously isolated product.Labeling experiments show that these dienes arise by intramolecular 1,4 transfer of hydrogen.Irradiation o
Total Synthesis and Antitrypanosomal Activity of Janadolide and Simplified Analogues
Chung, Jonathan H.,Corcilius, Leo,Geraghty, Kieran,Kaiser, Marcel,Payne, Richard J.,Tang, Arthur H.
supporting information, (2020/04/20)
Janadolide is a cyclic depsipeptide natural product isolated from the marine cyanobacterium Okeania sp. Herein, we describe the total synthesis of janadolide, along with eight simplified analogues, via an efficient solid-phase strategy. Crucial to the synthesis of the natural product was the construction of a key polyketide fragment via an enantioselective (-)-B-chlorodiisopinocampheylborane-mediated reduction and a B-alkyl Suzuki reaction. Janadolide and the simplified analogues exhibited antitrypanosomal activity against pathogenic Trypanosoma brucei rhodesiense and Trypanosoma cruzi parasites.
Synthesis of a key intermediate for the total synthesis of pseudopteroxazole
Yadav,Bhasker, E. Vijaya,Srihari
experimental part, p. 1997 - 2004 (2010/04/29)
A facile synthesis of a key intermediate for the total synthesis of anti-mycobacterial compound pseudopteroxazole is described employing an intramolecular Diels-Alder cyclization and an iodine-mediated oxidative aromatization step.
Synthesis of carbonyl and dicarbonyl compounds from organometallic reagents and N-imidazolium-N-methyl amides and bis-amides
De Las Heras, Maria A.,Vaquero, Juan J.,Garcia Navio, Jose L.,Alvarez-Builla, Julio
, p. 14297 - 14310 (2007/10/03)
A new method for the synthesis of selective acylating agents is described from the reaction of carboxylic acids with 3-methyl-1-methylamino-3H-imidazol-1-ium salts in the presence of appropriate coupling reagents. The amides and bis-amides thus prepared reacted selectively with organometallics to afford ketones and diketones and with DIBALH to give aldehydes and dialdehydes in high yields.
