72005-57-3

Basic information

• Product Name: 4-amino-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-5-(ethylsulfonyl)-2-methoxybenzamide 2,3-dihydroxybutanedioate (salt)
• CAS NO: 72005-57-3
• Molecular Formula: C₂₁H₃₃N₃O₁₀S
• Molecular Weight: 519.5658
• Mol File: 72005-57-3.mol

Chemical Properties

• Boiling Point: 558.9°C at 760 mmHg
• Flash Point: 291.8°C
• Vapor Pressure: 1.59E-12mmHg at 25°C
• CAS DataBase Reference: 4-amino-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-5-(ethylsulfonyl)-2-methoxybenzamide 2,3-dihydroxybutanedioate (salt)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-5-(ethylsulfonyl)-2-methoxybenzamide 2,3-dihydroxybutanedioate (salt)(72005-57-3)
• EPA Substance Registry System: 4-amino-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-5-(ethylsulfonyl)-2-methoxybenzamide 2,3-dihydroxybutanedioate (salt)(72005-57-3)

Safety Data

• Hazardous Substances Data: 72005-57-3(Hazardous Substances Data)

Upstream product

• 71675-85-9 amisulpride 
• 71675-87-1 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid 
• 22795-99-9 (S)-2-(Aminomethyl)-1-ethylpyrrolidine 
• 147-71-7 D-tartaric acid 
• 22795-97-7 (R)-2-aminomethyl-1-ethylpyrrolidine 
• 26116-12-1 1-ethyl-2-pyrrolidinemethanamine 
• 87-69-4 L-Tartaric acid 

Relevant articles and documents

CRYSTAL FORMS AND PRODUCTION METHODS THEREOF

The various aspects present inventions provide various crystalline forms of (S)-(?)-amisulpride, (R)-(+)-amisulpride, and solvates thereof and methods of making same. In various aspects, the inventions also provide methods of resolving racemic amisulpride.

R-amisulpride medicine salt, preparation method, crystal form and application thereof

The invention concretely relates to R-amisulpride medicine salt, a preparation method, a crystal form and application thereof in preparing a medicine for treating diabetes. The preparation method comprises the following steps: by adopting 2-aminomethyl-N-ethyl pyrrolidine as a raw material, and adopting L-tartaric acid, for splitting to obtain (R)-2-aminomethyl-N-ethyl pyrrolidine; directly condensing amisulpride acid and the (R)-2-aminomethyl-N-ethyl pyrrolidine under the catalysis of isopropyl chlorocarbonate and triethylamine, thus obtaining R-amisulpride; reacting the R-amisulpride obtained in the step (2) and acid to obtain the R-amisulpride medicine salt. The preparation method has the advantages of simplicity in operation, high safety, good product quality, low cost and the like, and is convenient for scale production.