72024-41-0

Upstream product

• 108-98-5 thiophenol 
• 3173-56-6 benzyl isothiocyanate 
• 13464-19-2 phenyl chlorothioformate 
• 100-46-9 benzylamine 
• 882-33-7 diphenyldisulfane 
• 1212-08-4 S-Phenyl benzenethiosulfonate 
• 88333-03-3 Benzyl isocyanide 
• 124-38-9 carbon dioxide 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 19093-37-9 allyl phenyl sulfoxide 
• 220573-65-9 diethyl 2-(phenylsulfinyl)succinate 
• 55543-78-7 (+/-)-Methyl 3-(Phenylsulfinyl)propanoate 
• 62076-10-2 (tert-butylsulfinyl)benzene 

Downstream Products

• 1323883-35-7 C₁₅H₁₅ClN₂O 
• 108-98-5 thiophenol 
• 1466-67-7 1,3-dibenzylurea 
• 92277-82-2 N-Benzyl-N'-(4-methylbenzyl)urea 
• 104385-10-6 N-benzyl-2,4,6-trimethylbenzamide 
• 882-33-7 diphenyldisulfane 

Relevant academic research and scientific papers

Synthesis of carbamothioate derivatives via a copper catalyzed thiocarboxamidation of aryl iodides

Abstract: A catalytic route to carbamothioate derivatives through a reaction involving isocyanides, elemental sulfur, and aryl iodides has been developed. The reaction scope has been examined using a range of isocyanides and aryl iodides. The reactions involve two consecutive C–S bond formations. Control experiment revealed that the reaction proceeds through an iminium species. Graphic abstract: [Figure not available: see fulltext.].

METHOD OF CONVERTING CARBON DIOXIDE INTO CARBONYL COMPOUNDS

The present invention provides a method for fixing carbon dioxide gas as a carbonyl compound represented by formula (3) as depicted by Figure 1 and comprising, purging of carbon dioxide in a solution of a nucleophile represented by the formula (1) in presence of a solvent at a temperature ranging from -40 Degree Celsius to 35 Degree Celsius, followed by adding a reagent at temperature ranging from -40 degree to 35 degree and thereafter adding another nucleophile represented by the formula (2) to obtain carbonyl compound represented by formula (3). The present invention can be advantageously used to obtain commercially important carbonyl compounds and clean unwanted carbon dioxide gas from the atmosphere and industrial effluents.

Investigations into the carbonic anhydrase inhibition of COS-releasing donor core motifs

Carbonyl sulfide (COS) releasing scaffolds are gaining popularity as hydrogen sulfide (H2S) donors through exploitation of the carbonic anhydrase (CA)-mediated hydrolysis of COS to H2S. The majority of compounds in this emerging class of donors undergo triggerable decomposition (often referred to as self-immolation) to release COS, and a handful of different COS-releasing structures have been reported. One benefit of this donation strategy is that numerous caged COS-containing core motifs are possible and are poised for development into self-immolative COS/H2S donors. Because the intermediate release of COS en route to H2S donation requires CA, it is important that the COS donor motifs do not inhibit CA directly. In this work, we investigate the cytotoxicity and CA inhibition properties of different caged COS donor cores, as well as caged CO2 and CS2 motifs and non-self-immolative control compounds. None of the compounds investigated exhibited significant cytotoxicity or enhanced cell proliferation at concentrations up to 100 μM in A549 cells, but we identified four core structures that function as CA inhibitors, thus providing a roadmap for the future development of self-immolative COS/H2S donor motifs.

Thermolysis-Induced Two- or Multicomponent Tandem Reactions Involving Isocyanides and Sulfenic-Acid-Generating Sulfoxides: Access to Diverse Sulfur-Containing Functional Scaffolds

Direct reaction of isocyanides with some sulfenic-acid-generating sulfoxides led to the effective formation of the corresponding thiocarbamic acid S-esters in good to high yields. A multicomponent reaction involving isocyanide, sulfoxide, and a suitable nucleophile has also been developed, providing ready access to a diverse range of sulfur-containing compounds, including isothioureas, carbonimidothioic acid esters, and carboximidothioic acid esters.

One-pot synthesis of carbamates and thiocarbamates from Boc-protected amines

A highly efficient one-pot procedure for the synthesis of carbamates and thiocarbamates has been described. In the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, the isocyanate intermediates were generated in situ for further reactions with alcohols and thiols to afford the desired carbamates and thiocarbamates in high yields.

Facile one-pot synthesis of unsymmetrical ureas, carbamates, and thiocarbamates from Cbz-protected amines

A novel one-pot synthesis of unsymmetrical ureas, carbamates and thiocarbamates from Cbz-protected amines has been developed. In the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, isocyanates are generated in situ, which facilitate rapid reaction with amines, alcohols, and thiols to afford the corresponding ureas, carbamates and thiocarbamates in high yields.

Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates

A new method for the synthesis of secondary thiocarbamates from readily available isocyanides and thiosulfonates with broad functional group tolerance is reported. The reaction proceeds under mild reaction conditions in isopropanol and is catalyzed by inexpensive sodium iodide.

SMALL MOLECULE ACTIVATORS AND INHIBITORS OF LECITHIN: CHOLESTEROL ACYLTRANSFERASE

The disclosure includes compounds and salts of Formula I, II, and III. The variables R, R0, R1, R10, R11, and R2 are defined herein. Compounds and salts of Formula I, II, and III are useful as modulat

Kinetics and mechanism of the aminolysis of aryl N-benzyl thiocarbamates in acetonitrile

The aminolysis reactions of phenyl N-benzyl thiocarbamate with benzylamines in acetonitrile at 50.0 °C are investigated. The reactions are first order in both the amine and the substrate. Under amine excess, pseudo-first coefficient (kobs) are obtained, plot of kobs vs free amine concentration are linear. The signs of ρXZ (X and ρZ with respect to the sustituent in the substrate and large ρXZ value indicate that the reactions proceed concerted mechanism. The normal kinetic isotope effects (kH/k D = 1.3 ～ 1.5) involving deuterated benzylamine nucleophiles suggest a hydrogen-bonded, four-centered-type transition state. The activation parameters, ΔH?and AS?, are consistent with this transition state structure.