72038-39-2

Usage

Uses

Used in Pharmaceutical Research:
4-[2-(diethylamino)ethyl]amino-4-oxobutanoic acid is used as a building block in pharmaceutical research for the development of potential drug candidates. Its diethylaminoethyl group improves the compound's bioavailability and cell membrane permeability, facilitating its delivery to target sites within the body.
Used in Organic Synthesis:
In the field of organic synthesis, 4-[2-(diethylamino)ethyl]amino-4-oxobutanoic acid serves as a versatile building block, enabling the creation of various complex organic molecules. Its unique structure and functional groups allow for a wide range of chemical reactions and modifications, making it a valuable component in the synthesis of novel compounds.
Used in Materials Science:
4-[2-(diethylamino)ethyl]amino-4-oxobutanoic acid also finds applications in materials science, where its unique properties can be harnessed to develop new materials with specific characteristics. 4-[2-(diethylamino)ethyl]amino-4-oxobutanoic acid's reactivity and structural features can be exploited to create materials with tailored properties for various applications, such as sensors, catalysts, or advanced materials for energy storage and conversion.

Upstream product

• 110-15-6 succinic acid 
• 100-36-7 N,N-diethylethylenediamine 

Relevant academic research and scientific papers

Polarity-Tuning Derivatization-LC-MS Approach for Probing Global Carboxyl-Containing Metabolites in Colorectal Cancer

Carboxyl-containing metabolites (CCMs) widely exist in living systems and are the essential components for life. Global characteristics of CCMs in biological samples are critical for the understanding of physiological processes and the discovery for the onset of relevant diseases. However, their determination represents a challenge due to enormous polarity differences, structural diversity, high structural similarity, and poor ionization efficiency in mass spectrometry. Herein, 5-(diisopropylamino)amylamine (DIAAA) derivatization coupled with liquid chromatography-mass spectrometry (LC-MS) was developed for mapping the CCMs. With this methodology, the sensitivity was significantly enhanced. More importantly, the hydrophobicity of polar CCMs, amino acids, TCA cycle intermediates, and short-chain fatty acids and the hydrophilicity of low-polar CCMs, long-chain fatty acids, and bile acids were significantly increased, resulting in a remarkable separation efficiency for which 68 CCMs can be simultaneously determined. Furthermore, the polarity-tuning effect was confirmed to be induced by the different impacts of aliphatic chains and nitrogen atom in DIAAA, the latter existing as a cation in the acidic mobile phase, using different derivatization reagents. Finally, this derivatization method was utilized to hunt for the potential biomarkers in colorectal cancer (CRC) patients and 52 CCMs, related with several key metabolic pathways, including amino acids metabolism, TCA cycle, fatty acid metabolism, pyruvate metabolism, and gut flora metabolism were identified. This innovative polarity-tuning derivatization-LC-MS approach was proved to be a valuable tool for probing global metabolome with high separation efficiency and sensitivity in various biological samples.