7205-16-5Relevant articles and documents
Synthetic method for benzyl thiophosphate
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Paragraph 0028-0029, (2019/02/06)
The invention provides a synthetic method for benzyl thiophosphate. The method comprises the step of carrying out a stirring reaction for 6-24 hours on benzyl alcohol which is cheap and easily available, wide in source and stable and low in toxicity as an alkylation reagent and sulfur powder and phosphite ester to prepare a benzyl thiophosphate compound in one step at 70-100 DEG C without a catalyst. The method is simple in reaction condition, the raw materials are easily available, excessive alkali is not used, a solvent is not needed, and the method is easy to operate with only one reaction.The method can be also used for amplifying and gram-grade preparation of products conveniently, and has certain research and industrial application prospects.
Synthesis of Thiophosphates by Coupling of Phosphates with Bunte Salts under Mild Conditions
Min, Cong,Zhang, Rongxing,Liu, Qian,Lin, Sen,Yan, Zhaohua
supporting information, p. 2027 - 2030 (2018/09/14)
A simple, green, and efficient method has been developed for the preparation of thiophosphates with sodium S-benzyl thiosulfates. The method uses an NaBr-catalyzed coupling reaction of Bunte salts with phosphonates in the presence of an acid and hydrogen peroxide (30%), and the desired products were obtained in good yields.
NHC-Catalyzed Metathesis and Phosphorylation Reactions of Disulfides: Development and Mechanistic Insights
Crocker, Reece D.,Hussein, Mohanad A.,Ho, Junming,Nguyen, Thanh V.
supporting information, p. 6259 - 6263 (2017/05/12)
The development of efficient methods for the metathesis and phosphorylation reactions of disulfide compounds is of widespread interest due to their important synthetic utility in polymer, biological, medicinal and agricultural chemistry. Herein, we demonstrate the use of N-heterocyclic carbenes (NHCs) as versatile organocatalysts to promote these challenging reactions under mild conditions. This metal- and oxidant-free protocol is operationally simple with very short reaction times. The interplay between the nucleophilicity and basicity of NHCs in these reactions were also elucidated by NMR studies and high-level ab initio calculations.
N-Chlorosuccinimide-promoted synthesis of thiophosphates from thiols and phosphonates under mild conditions
Liu, Yi-Chen,Lee, Chin-Fa
, p. 357 - 364 (2014/01/06)
A very simple N-chlorosuccinimide-promoted synthesis of thiophosphates through the coupling of thiols and phosphonates is reported. Notably, the reactions were carried out in the absence of a base. Functional groups including fluoro, bromo and trifluoromethyl are all tolerated by the reaction conditions employed. Both aryl and alkyl thiols are coupled smoothly with a broad spectrum of phosphonates to afford the corresponding thiophosphates in good to excellent yields.
Phosphorothioate synthesis based on the redox reaction of phosphite with tellurium(IV) chloride
Watanabe,Inoue,Yamamoto,Ozaki
, p. 1243 - 1244 (2007/10/02)
Phosphoric thiol esters are conveniently prepared by the treatment of phosphorous triesters with thiols in the presence of tellurium(IV) chloride in a redox-type reaction.
A new synthesis of thiophosphoric acid esters with a C-S-P bond
Muller,Roth
, p. 501 - 502 (2007/10/02)
Various S-substituted thiosuccinimides 1a-d and thiophthalimides 2a-d were found to react with trialkylphosphites according to a Michaelis-Arbuzov type mechanism. This provides an efficient way to prepare thiophosphoric acid esters, particularly thiophospholipids, with a C-S-P bond.
