4093-29-2

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-acetamido-2-methoxybenzoate is used as an impurity in bromopride for its role in the development and manufacturing process of the antiemetic drug. It is essential to monitor and control the presence of this impurity to ensure the safety, efficacy, and quality of bromopride as a medication for treating nausea and vomiting.

InChI:InChI=1/C11H13NO4/c1-7(13)12-8-4-5-9(11(14)16-3)10(6-8)15-2/h4-6H,1-3H3,(H,12,13)

Upstream product

• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 
• 108-24-7 acetic anhydride 
• 50-86-2 4-acetamidosalicylic acid 
• 77-78-1 dimethyl sulfate 
• 4093-28-1 methyl 4-acetamido-2-hydroxybenzoate 
• 74-88-4 methyl iodide 
• 65-49-6 4-Aminosalicylic acid 
• 4136-97-4 methyl 4-aminosalicylate 
• 584-08-7 potassium carbonate 
• 67-56-1 methanol 
• 55304-05-7 4-acetylamino-2-methoxy-benzoic acid 
• 75-36-5 acetyl chloride 
• 39106-79-1 methyl 2-methoxy-4-nitrobenzoate 

Downstream Products

• 94978-69-5 4-(acetylamino)-2-methoxy-N-<1-(phenylmethyl)-4-piperidinyl>benzamide 
• 2486-80-8 4-amino-2-methoxybenzoic acid 
• 4093-31-6 methyl 2-methoxy 4-acetamido 5-chloro benzoate 
• 80194-49-6 4-acetamido-2-methoxybenzyl alcohol 
• 4093-41-8 methyl 4-acetamido-2-methoxy-5-nitrobenzoate 
• 201214-53-1 methyl 4-acetamido-5-iodo-2-methoxybenzoate 
• 565184-69-2 4-acetylamino-5-(1-benzenesulfonyl-3-phenylsulfanyl-1H-indole-2-carbonyl)-2-methoxy-benzoic acid methyl ester 
• 500015-98-5 4-acetylamino-5-(1-benzenesulfonyl-1H-indole-2-carbonyl)-2-methoxy-benzoic acid methyl ester 
• 57645-41-7 4-amino-N-(1-benzyl-piperidin-4-yl)-2-methoxy-benzamide 
• 94978-70-8 iodoclebopride 
• 1304076-79-6 2-hydroxybenzal-(4'-acetamido-2'-methoxybenzoyl)hydrazine 
• 1304076-80-9 4-hydroxybenzal-(4'-acetamido-2'-methoxybenzoyl)hydrazine 
• 908089-55-4 4-hydroxy-3-methoxy-benzal-(4'-acetamido-2'-methoxybenzoyl)hydrazine 
• 1304076-86-5 C₁₉H₁₉N₃O₄S 

Relevant academic research and scientific papers

ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I' PATHWAY AND METHODS OF USE THEREOF

The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.

ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I" PATHWAY AND METHODS OF USE THEREOF

The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.

As neuroprotective agents of pharmaceutical compounds

The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.

Substituted benzene and heterocyclic compound and its preparation method and application

The invention provides substituted benzoheterocyclic compounds and a preparation method thereof. The compounds have structures shown by formulas I and II. The invention also provides the effects of the compounds shown by formulas I and II in resisting virus, tumor and the like. The invention further provides a medicine composition taking the compounds shown by the formulas I and II as active ingredients, and the anti-virus or anti-tumor effect of the medicine composition. The invention lays a foundation for the future in-depth study and development of the anti-virus or anti-tumor medicine of the compounds.

QUINAZOLINE-BASED KINASE INHIBITORS

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

ANTIVIRAL COMPOUNDS

Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

ARYL AMIDE KINASE INHIBITORS

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

Synthesis and biological evaluation of berberine derivatives as IBS modulator

Irritable bowel syndrome is the most common functional gastrointestinal disorder characterized by chronic abdominal pain or discomfort in association with a change in bowel habit. 5-HT receptor modulators have been developed as IBS therapeutic agents and proved to be effective in the treatment of the disease. In this letter, 12 berberine derivatives were designed and synthesized as 5-HT receptor modulators. Preliminary biological tests suggested that the new compounds exhibited promising activity for IBS therapy.

RADIOPROTECTOR COMPOUNDS AND METHODS

The invention relates to novel compounds, processes for their preparation and their use in protecting biological materials from radiation damage (radioprotection). Preferred compounds of the invention are those of Formula (II), as follows: wherein W represents -N(R1R2) where R1 and R2 are not both hydrogen and where they may together form a 5, 6 or 7 membered ring structure, -NHN(R1R2), NHR3N(R1R2), -NHR3OR2, -N(R3)R3OR2, -N(R1)R3OR3OR3, OR3NR1R2, -OR3 or W represents piperidyl, piperazinyl, morpholinyl, thiomorpholinyl or diazepanyl each of which may be optionally substituted by C1 to C4 alkyl, C2 to C4 alkenyl, -N(CO)N(R1R2), -N(CO)OR1, -N(CO)OR3OH, -(CO)NR1R2, -R3(CO)NR1R2, -R3OR1, -OR1, -N(R1R2) OR -NH-; R1 and R2 are the or different and are selected from hydrogen, C1 to C4 alkyl or C2 to C4 alkenyl; group or chain; Z is the same or different and represents N or CH; Z' is the same or different and represents N or C; X represents CH, N or NH, where .. is a double bond when X is CH or N and a single bond when X is NH; X' represents N or NH, wherein when X is CH or N X' is NH and wherein X and X' are different and further where ～～～is a double bond when X' is N and a single bond when X' is NH; Q represents H, alkoxyl, -NR1R2, F or Cl; Q1 is absent when Z' is N and when Z' is C it represents H, alkoxyl, -NR1R2, F or Cl; A represents a five to ten membered single or multiple ring structure with heterocyclic N or O located at the ortho position, said ring including optional double bonds, substitutions and/or other heteroatoms and pharmaceutically acceptable derivatives thereof.

Syntheses of some thiazolidin-4-ones as potential antimicrobial agents

4-Acetamido-2-methoxybenzoyl hydrazine (1) on condensation with different aromatic aldehydes yielded the substituted benzal-(4'- acetamido-2'- methoxybenzoyl)hydrazines (2a-f) which on cyclization with thioglycolic acid in presence of anhydrous aluminium chloride as catalyst afforded 2-(substituted phenyl)-3-(4'-acetamido-2'-methoxy benzamido)-5-H-thiazolidin-4-ones (3a-f). The structures of the newly synthesized compounds have been established by analytical and spectral methods. These compounds have also been screened for their biological activity.