72093-03-9

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-2-methylpyridine is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be incorporated into the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Chloro-2-methylpyridine is employed as a precursor in the production of various agrochemicals. Its reactivity and structural properties make it suitable for the creation of compounds that can be used in crop protection and pest management.
Used in Organic Synthesis:
3-Chloro-2-methylpyridine is utilized as a building block in organic synthesis, enabling the construction of complex organic molecules. Its presence in the synthesis process allows for the development of a wide range of organic compounds with diverse applications in various industries.
Used in Chemical Manufacturing:
3-CHLORO-2-METHYLPYRIDINE is also used in the manufacturing of various chemicals, where its properties can be leveraged to produce a multitude of chemical products. Its versatility and reactivity make it a valuable component in the chemical industry.

InChI:InChI=1/C6H6ClN/c1-5-6(7)3-2-4-8-5/h2-4H,1H3

Upstream product

• 137778-19-9 3-chloro-2-methyl-6-pyridinecarboxylic acid 
• 626-60-8 3-Chloropyridine 
• 3430-10-2 2-methyl-3-pyridinamine 
• 2402-77-9 2,3-dichloro-pyridine 
• 75-16-1 methylmagnesium bromide 
• 137778-09-7 3-chloro-2-methyl-6-pyridylmethanol 
• 137778-17-7 3-chloro-6-formyl-2-methylpyridine 
• 3512-76-3 3-chloro-2,6-dimethylpyridine N-oxide 

Downstream Products

• 57266-69-0 3-chloropyridine-2-carboxylic acid 
• 60588-81-0 3-chloro-2-hydroxy-methyl-pyridine 
• 206181-90-0 3-chloropyridine-2-carboxaldehyde 
• 1217744-61-0 3-((3-chloropyridin-2-yl)methyl)-5-methylcyclohexanone 
• 1217744-62-1 (3-((3-chloropyridin-2-yl)methyl)-5-methylcyclohex-1-enyloxy)trimethylsilane 

Relevant academic research and scientific papers

A chloro pyridine and its derivatives synthetic method

The invention discloses a method for synthesizing chloropyridines and derivatives thereof and belongs to the field of fine chemical industry. According to the method, aminopyridine and derivatives thereof undergo a reaction to generate chloropyridines and derivatives thereof. The method is characterized in that phosphorus trichloride, phosphorus oxychloride or thionyl chloride and nitric acid are added into a solution of aminopyridine and the derivatives of aminopyridine, and chloropyridines and derivatives of chloropyridines can be obtained by stirring and reaction. The method has the advantages of being simple to operate, high in yield and less in three wastes.

Chemoselective sp 2-sp3 cross-couplings: Iron-catalyzed alkyl transfer to dihaloaromatics

The chemoselective functionalization of a range of dihaloaromatics with methyl, cyclopropyl, and higher alkyl Grignard reagents via iron-catalyzed cross-coupling is described. The site selectivity of C-X (X = halogen) activation is determined by factors such as the position of the halogen on the ring, the solvent, and the nucleophile. A one-pot protocol for the chemoselective synthesis of mixed dialkyl heterocycles is achieved solely employing iron catalysis.

Nucleophilic addition to 3-substituted pyridinium salts: Expedient syntheses of (-)-L-733,061 and (-)-CP-99,994

(Chemical Equation Presented) The addition of nucleophiles to 3-substituted pyridinium salts prepared from N-methylbenzamide and various pyridines has been investigated. Good to excellent regioselectivities favoring the 2,3-disubstituted 1,2-dihydropyridines were observed. The resulting 1,2-dihydropyridines led to the corresponding 2,3-disubstituted pyridines upon treatment with Mn(OAc)3/NaIO4. This methodology was also successfully applied to the enantioselective syntheses of (-)-L-733,061 and (-)-CP-99,994, two members of a new class of highly potent, nonpeptide, Substance P antagonists.

THE REARRANGEMENT OF 3-CHLORO- AND 3-BROMO-2,6-DIMETHYLPYRIDINE N-OXIDE UNDER THE ACTION OF ACETIC ANHYDRIDE

The rearrangement of 3-chloro and 3-bromo-2,6-dimethylpyridine N oxides under the influence of acetic anhydride was investigated.The rearrangement products: 3-halo-2-methyyl-6-pyridylmethanol and 3-halo-2,6-dimethyl-5-hydroxypyridine acetates were separated and hydrolyzed to corresponding alcohols. 3-Halo-2-methyl-6-pyridylmethanols were oxidized to aldehydes and carboxylic acids.Structures of pyridylmethanols and hydroxy derivatives have been determined by IR spectra analysis or by chemical methods.