206181-90-0

Basic information

• Product Name: 3-Chloropyridine-2-carboxaldehyde
• Synonyms: 3-Chloropyridine-2-carboxaldehyde;2-Pyridinecarboxaldehyde,3-chloro-(9CI);3-Chloro-2-formylpyridine;3-chloropicolinaldehyde;3-chloropyridine-2-carbaldehyde;3-chloropyridine-4-carbaldehyde;2-Pyridinecarboxaldehyde, 3-chloro-;3-chloro-2-Pyridinecarboxaldehyde
• CAS NO: 206181-90-0
• Molecular Formula: C₆H₄ClNO
• Molecular Weight: 141.55506
• Product Categories: PYRIDINE;Building Blocks;Heterocycle-Pyridine series
• Mol File: 206181-90-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 202℃
• Flash Point: 76℃
• Appearance: /
• Density: 1.332
• Vapor Pressure: 0.306mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.12±0.10(Predicted)
• CAS DataBase Reference: 3-Chloropyridine-2-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloropyridine-2-carboxaldehyde(206181-90-0)
• EPA Substance Registry System: 3-Chloropyridine-2-carboxaldehyde(206181-90-0)

Safety Data

• Hazardous Substances Data: 206181-90-0(Hazardous Substances Data)

Usage

General Description

3-Chloropyridine-2-carboxaldehyde is a chemical compound with the molecular formula C6H4ClNO. It is a pale yellow liquid with a pungent odor and is soluble in organic solvents. 3-Chloropyridine-2-carboxaldehyde is used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used in the production of dyes and pigments. 3-Chloropyridine-2-carboxaldehyde is a versatile building block in organic chemistry, and it is important in the manufacturing of various commercial products. It is important to handle this compound with care, as it is a hazardous material that can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C6H4ClNO/c7-5-2-1-3-8-6(5)4-9/h1-4H

Upstream product

• 60588-81-0 3-chloro-2-hydroxy-methyl-pyridine 
• 96424-68-9 2-bromo-3-chloropyridine 
• 204569-87-9 3-chloro-2-vinylpyridine 
• 626-60-8 3-Chloropyridine 
• 24721-92-4 1-Dimethylamino-ethanol 
• 96042-30-7 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 
• 7757-82-6 sodium sulfate 
• 72093-03-9 3-chloro-2-methylpyridine 
• 57266-69-0 3-chloropyridine-2-carboxylic acid 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

Synthesis method of (R)-3-chloropyridyl-2-trifluoroethylamine hydrochloride

The invention discloses a synthesis method of (R)-3-chloropyridyl-2-trifluoroethylamine hydrochloride, and the synthesis method is characterized in that a Grignard reaction, a chiral induction addition reaction and a deprotection reaction are sequentially carried out to finally prepare a finished product. The invention provides a brand-new synthesis method of the (R)-3-chloropyridyl-2-trifluoroethylamine hydrochloride for the first time. The synthetic method is short in route, raw materials are easy to obtain, operation is easy, a continuous flow microreactor technology is adopted in the first step, reactants are rapidly and effectively mixed, the reaction time and the reaction temperature are accurately controlled, side reactions are avoided, and the conversion rate and safety are effectively improved. The compound 4 with high chiral purity is obtained through chiral induction addition reaction and recrystallization purification, and the de value of the compound 4 is greater than 99.5%. The post-treatment method is simple in post-treatment operation, column chromatography treatment is not needed after each step of reaction, reactants can be purified only through washing and extraction of a solvent, and the method is a novel post-treatment purification method.

METHOD FOR PRODUCING BENZOXAZOLE COMPOUND

PROBLEM TO BE SOLVED: To provide a new method for producing a benzoxazole compound represented by formula (1) (R is a chain hydrocarbon group; n is 0-3; X is a halogen atom, -SR1 or -S(O)2R1; R1 is a chain hydrocarbon group or the like). SOLUTION: The benzoxazole compound is obtained through the reaction of a compound represented by formula (2) and formula (3) in the presence of oxidizing agent. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

Substituted Spiro Compounds and Their Use for Producing Pain-Relief Medicaments

The present invention relates to substituted spiro compounds, to processes for preparing them, to medicaments comprising these compounds and to the use of these compounds for producing medicaments.