721-68-6

Basic information

• Product Name: 3,3,3-trifluoro-1-(4-nitrophenyl)propan-1-one
• Synonyms: 3,3,3-trifluoro-1-(4-nitrophenyl)propan-1-one
• CAS NO: 721-68-6
• Molecular Weight: 233.147
• Mol File: 721-68-6.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 3,3,3-trifluoro-1-(4-nitrophenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3,3-trifluoro-1-(4-nitrophenyl)propan-1-one(721-68-6)
• EPA Substance Registry System: 3,3,3-trifluoro-1-(4-nitrophenyl)propan-1-one(721-68-6)

Safety Data

• Hazardous Substances Data: 721-68-6(Hazardous Substances Data)

Upstream product

• 100-13-0 4-nitrostyrene 
• 147531-11-1 trifluoromethanesulfonic acid diphenyl(trifluoromethyl)sulfonium salt 
• 555-16-8 4-nitrobenzaldehdye 
• 22391-01-1 1-(4-nitrophenyl)-1-(acetyloxy)ethylene 
• 2926-29-6 Langlois reagent 
• 56039-43-1 1-(4-nitrophenyl)vinyl trifluoromethanesulfonate 
• 68760-11-2 1-(4-nitrophenyl)-3-N,N-dimethylamino-2-propen-1-one 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 77570-32-2 ethyl 3-amino-3-(4-nitrophenyl)-2-propenoate 
• 421-83-0 trifluoromethane sulfonyl chloride 
• 619-89-6 p-nitrocinnamic acid 
• 99-81-0 4-Nitrophenacyl bromide 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 111269-45-5 3-(Dimethyl-hydrazono)-1,1,1-trifluoro-3-(4-nitro-phenyl)-propan-2-one 

Downstream Products

• 7119-18-8 4-Dimethylamino-4'-<3,3,3-trifluor-propionyl>-azobenzol 

Relevant articles and documents

Scissoring Enaminone C=C Double Bond by Free Radical Process for the Synthesis of α-Trifluoromethyl Ketones with CF3SO2Na

The C=C double bond cleavage on tertiary enaminones, enabling the formation of a new C-CF3 bond, has been realized as a practical method for the synthesis of α-trifluoromethyl ketones with only the promotion of TBHP and ambient heating. Control experiments support that the reactions proceed via a featured free radical process. The deuterium labeling experiment employing D2O indicates that water participated in the product formation by donating the hydrogen atom for the newly generated α-C-H bond in the product.

Radical Desulfur-Fragmentation and Reconstruction of Enol Triflates: Facile Access to α-Trifluoromethyl Ketones

We report an efficient oxidative radical desulfur-fragmentation and reconstruction of enol triflates for the synthesis of α-CF3ketones. Preliminary mechanistic studies disclosed that oxidative fragmentation to release a CF3radical fr

Fenton reagent-catalyzed trifluoromethylation of enamines of 3-oxocarboxylates with CF3I

The trifluoromethylation of enamines of ethyl 3-oxocarboxylates catalyzed by Fenton reagent with CF3I was investigated. Trifluoromethylation followed by acid hydrolysis provided 3-oxo-2-(trifluoromethyl)carboxylates in 64-94% yields, which were greater than those obtained by the trifluoromethylation of 3-oxocarboxylates as reported previously. Enamines trifluoromethylated at the 2-position were isolated as intermediates. Hydrolysis and successive decarboxylation of the obtained 3-oxo-2-(trifluoromethyl)carboxylates under acidic conditions provided (2,2,2-trifluoroethyl)ketones in satisfactory yields.