77570-32-2Relevant academic research and scientific papers
ESR spectra of free radicals of 3,3-disubstituted 1,2,3,4-tetrahydropyridines produced during electrochemical reduction
Gavars,Baumane,Stradyn',Chekavichus,Duburs
, p. 950 - 956 (1998)
The polarographic properties (potentials, number of electrons, reversibility) of the electrochemical reduction of 3,5-diethoxycarbonyl-3-(p-nitrobenzoyl)-6-(p-nitrophenyl)-1,2,3,4- tetrahydropyridine and its derivatives in dimethylformamide have been dete
Cu-Mediated Expeditious Annulation of Alkyl 3-Aminoacrylates with Aryldiazonium Salts: Access to Alkyl N2-Aryl 1,2,3-Triazole-carboxylates for Druglike Molecular Synthesis
Liu, Hao-Nan,Cao, Hao-Qiang,Cheung, Chi Wai,Ma, Jun-An
supporting information, p. 1396 - 1401 (2020/02/22)
Alkyl N-aryl 1,2,3-triazole-carboxylates are important molecules or intermediates in medicinal chemistry, but the synthesis of N2-aryl counterparts remains elusive. Herein, we describe a Cu-mediated annulation reaction of alkyl 3-aminoacrylates with aryldiazonium salts, both of which are readily available substrates. Furthermore, alkyl 2-aminoacrylates are also viable substrates. Diverse alkyl N2-aryl 1,2,3-triazole-carboxylates and their analogues can be rapidly prepared under mild conditions. Especially, this protocol allows one to access several druglike variants of carbonic anhydrase inhibitors and celecoxib.
Synthesis of Thiazoles and Isothiazoles via Three-Component Reaction of Enaminoesters, Sulfur, and Bromodifluoroacetamides/Esters
Ma, Xingxing,Yu, Xiaoxia,Huang, Hua,Zhou, Yao,Song, Qiuling
supporting information, p. 5284 - 5288 (2020/07/14)
A three-component strategy for the synthesis of thiazoles and isothiazoles has been developed by employing enaminoesters, fluorodibromoiamides/ester, and sulfur. The thiazoles and isothiazoles were formed via two C-F bond cleavages along with the formation of new C-S, C-N, and N-S bonds. The strategy provides high selectivity for the synthesis of thiazoles/isothiazoles, which have vital applications in drug discovery and development.
Facile Synthesis of Onychines
Arita, Mao,Yokoyama, Soichi,Asahara, Haruyasu,Nishiwaki, Nagatoshi
, p. 2007 - 2013 (2019/04/26)
The FeCl 3 -mediated condensation of an α-phenylenamino ester and an enone proceeds efficiently to afford a 2-phenylnicotinate. The subsequent intramolecular Friedel-Crafts reaction yielded an onychine framework. Modifications at the 2-, 3-, and 8-positions of the onychine framework were easily achieved by altering the enamino esters and enones, which facilitated the discovery of potentially bioactive compounds.
Cu-Catalyzed Denitrogenative Transannulation of 3-Aminoindazoles to Assemble 1-Aminoisoquinolines and 3-Aminobenzothiophenes
Zhou, Yao,Wang, Ya,Lou, Yixian,Song, Qiuling
supporting information, p. 8869 - 8873 (2019/09/12)
We disclose a novel Cu-catalyzed denitrogenative transannulation of 3-aminoindazoles to afford diverse functionalized 3-aminobenzothiophenes and 1-aminoisoquinolines, in which denitrogenative transannulation of 3-aminoindazoles is reported for the first t
Efficient synthesis of β-amino-α,β-unsaturated carbonyl compounds
Zhao, Yuanhong,Zhao, Jingfeng,Zhou, Yongyun,Lei, Ze,Li, Liang,Zhang, Hongbin
, p. 769 - 772 (2007/10/03)
A versatile and high-yielding procedure for the synthesis of β-enamino esters and β-enaminones is presented: in the presence of tetraethyl orthosilicate, a number of highly functional β-enamino esters were obtained; this method provided an alternative for the formation of β-amino-α,β-unsaturated carbonyl compounds with mild and functional group compatible reaction conditions. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2005.
Dioxopyrrolines. XXVII. Syntheses of 2-Aryl-3-ethoxycarbonyl-Δ2-pyrroline-4,5-diones
Sano, Takehiro,Horiguchi, Yoshie,Toda, Jun,Imafuku, Kazue,Tsuda, Yoshisuke
, p. 497 - 503 (2007/10/02)
2-Aryl-3-ethoxycarbonyl-Δ2-pyrroline-4,5-diones (3) were easily prepared in good yields by condensation of enamino-esters (2) with oxalyl chloride.The products were characterized by ultraviolet and infrared spectroscopy. Keywords - Δ2-pyrroline-4,5-dione; dioxopyrroline; enamino-ester; ethyl 3-aryl-3-aminopropenoate; 2-aryl-3-ethoxycarbonyl-Δ2-pyrroline-4,5-dione; UV; restricted rotation
