72105-98-7

Upstream product

• 3261-62-9 2-(p-tolyl)ethylamine 
• 100-52-7 benzaldehyde 
• 98-88-4 benzoyl chloride 
• 72105-96-5 7-methyl-1-phenyl-3,4-dihydroisoquinoline 
• 3278-15-7 N-(4-methylphenethyl)benzamide 

Downstream Products

• 1229515-36-9 4-(7-methyl-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-4-oxobutyric acid 
• 72105-96-5 7-methyl-1-phenyl-3,4-dihydroisoquinoline 

Relevant academic research and scientific papers

Enhancement of the carbamate activation rate enabled syntheses of tetracyclic benzolactams: 8-oxoberbines and their 5- And 7-membered C-ring homologues

A route to the direct amidation of aromatic-ring-tetheredN-carbamoyl tetrahydroisoquinoline substrates was developed. This route enabled general access to 8-oxoberberines and their 5- and 7- membered C-ring homologues. It overcomes the undesired tandem side-reactions that result in the destruction of the isoquinoline backbone, which inevitably occurred under our previously reported superacidic carbamate activation method.

SUBSTITUTED 4-(1,2,3,4-TETRAHYDROISOQUINOLIN-2-YL)-4-OXORUTYRIC ACID AMIDE AS KCNQ2/3 MODULATORS

The invention relates to substituted tetrahydroisoquinolinyl-4-oxobutyric acid amides, methods for the preparation thereof, medicinal products containing these compounds and the use of these compounds for the preparation of medicinal products