72109-66-1Relevant academic research and scientific papers
Bimetallic Bis-anion Cascade Complexes of Magnesium in Nonaqueous Solution
Carta, Veronica,Flood, Amar H.,Flynn, Ian G.,Van Craen, David
, (2020/05/05)
Bimetallic magnesium(II) complexes are gaining significant interest in catalysis, yet their fundamental formation and behavior in organic media remain surprisingly unexplored relative to other divalent cations. To understand key principles of their formation, we investigate symmetric ditopic ligands bearing a phenolic backbone and characterize their ability to form dinuclear magnesium(II) cascade complexes with two bridging anions. High-fidelity production of bimetallic magnesium complexes relative to the monometallic complexes is indicative of positive cooperativity. Binding and recognition of analytes or substrates is a key characteristic of metal cascade complexes and relies on anion exchange, but this is also rarely studied with bimetallic magnesium complexes. Investigations with acetate, phosphate, and pyrophosphate reveal exchange of bridging nitrates using the bis-dipicolylamine complex. Rare seven-coordinate magnesium centers are found for the ester complex. The findings in this study provide formative steps to establish design principles for future generations of bimetallic magnesium(II) complexes.
The role of Zn-OR and Zn-OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics
Daumann, Lena J.,Dalle, Kristian E.,Schenk, Gerhard,McGeary, Ross P.,Bernhardt, Paul V.,Ollis, David L.,Gahan, Lawrence R.
experimental part, p. 1695 - 1708 (2012/03/22)
Analogues of the ligand 2,2′-(2-hydroxy-5-methyl-1,3-phenylene) bis(methylene)bis((pyridin-2-ylmethyl)azanediyl)diethanol (CH3H 3L1) are described. Complexation of these analogues, 2,6-bis(((2-methoxyethyl)(pyridin-2-ylmethyl)amino)m
Triostin A derived hybrid for simultaneous DNA binding and metal coordination
Sachs, Eike-F.,Nadler, Andre,Diederichsen, Ulf
experimental part, p. 449 - 456 (2012/04/04)
The natural product triostin A is known as an antibiotic based on specific DNA recognition. Structurally, a bicyclic depsipeptide backbone provides a well-defined scaffold preorganizing the recognition motifs for bisintercalation. Replacing the intercalating quinoxaline moieties of triostin A by nucleobases results in a potential major groove binder. The functionalization of this DNA binding triostin A analog with a metal binding ligand system is reported, thereby generating a hybrid molecule with DNA binding and metal coordinating capability. Transition metal ions can be placed in close proximity to dsDNA by means of non-covalent interactions. The synthesis of the nucleobase-modified triostin A analog is described containing a propargylglycine for later attachment of the ligand by click-chemistry. As ligand, two [1,4,7] triazacyclononane rings were bridged by a phenol. Formation of the proposed binuclear zinc complex was confirmed for the ligand and the triostin A analog/ligand construct by high-resolution mass spectrometry. The complex as well as the respective hybrid led to stabilization of dsDNA, thus implying that metal complexation and DNA binding are independent processes.
Syntheses of biphenyl analogues of AP7, a new class of competitive N-methyl-D-aspartate (NMDA) receptor antagonists
Muller,Kipfer,Lowe,Urwyler
, p. 2026 - 2035 (2007/10/02)
Affinities for the NMDA receptor were measured ([3H]CGP-39653 binding assay) and competitive NMDA antagonistic potencies determined in a functional test (rat neocortical slice preparation). Structure-activity relationships show that attachment
