7211-57-6

Usage

InChI:InChI=1/C6H11NO3/c1-3-5(6(9)10)7-4(2)8/h5H,3H2,1-2H3,(H,7,8)(H,9,10)

Upstream product

• 108-24-7 acetic anhydride 
• 2835-81-6 2-aminobutanoic acid 
• 64-19-7 acetic acid 
• 60-35-5 acetamide 
• 123-38-6 propionaldehyde 
• 201230-82-2 carbon monoxide 
• 107-18-6 allyl alcohol 
• 75-56-9 methyloxirane 
• 692-33-1 N-allylacetamide 

Downstream Products

• 57357-44-5 (Di-N-acetyl-α-aminobutyryloxyjod)-benzol 
• 66927-32-0 (4-ethyl-2-methyl-oxazol-5-yl)-diphenyl-amine 
• 66927-25-1 2-Acetylamino-N,N-diphenyl-butyramide 
• 94664-19-4 3-Acetyl-4-ethyl-5-oxazolidinone 
• 1492-24-6 L-2-aminobutyric acid 
• 34271-27-7 (R)-2-acetylamino-butyric acid 
• 114285-09-5 C₆H₁₀NO₃ 
• 81217-06-3 2-Acetylamino-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-butyramide 
• 2835-81-6 2-aminobutanoic acid 
• 7682-14-6 N-acetyl-D-2-aminobutyric acid 
• 7682-14-6 N-acetyl-L-2-aminobutyric acid 

Relevant academic research and scientific papers

Amidoearbonylation of aldehydes utilizing cobalt oxide-supported gold nanoparticles as a heterogeneous catalyst

Cobalt oxide-supported gold-nanoparticles-catalyzed transformation of aldehydes and their equivalents to N-acyl-α-arnino acids was achieved. The desired products were obtained in moderate to excellent yields under milder reaction conditions than previous reports employing octacarbonyldicobalt as a catalyst. Copyright

Application of aminoacylase I to the enantioselective resolution of α-amino acid esters and amides

Aminoacylase I from Aspergillus melleus, a readily available and inexpensive enzyme mainly used in the industrial production of enantiopure L-amino acids from their N-acetyl derivatives, is shown to hydrolyze the esters and amides of natural and non-natural amino acids with high enantioselectivity (for the ester hydrolysis, E is up to 76, in case of amides E >300). The reaction rates of amide and ester hydrolysis are comparable, and in some cases these conversions proceeded even faster than 'traditional' aminoacylase- catalyzed hydrolysis of N-acetyl derivatives thus providing new possibilities for the resolution of the corresponding racemates. This novel approach provides an alternative route for the biocatalytic production of optically active amino acids and their derivatives.

Novel heterocycles 3

The invention relates to 7-(4-tert butyl-cyclohexyl)-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

Synthesis of N-Acetyl-α-aminobutyric Acid via Amidocarbonylation: A Case Study

The synthesis of N-acetyl-α-aminobutyric acid by amidocarbonylation of propionaldehyde with acetamide in the presence of palladium catalysts is studied in detail. The influence of various reaction conditions and compositions (e.g., the co-catalysts acid and bromide) on the yield of N-acetyl-α-aminobutyric acid is shown. For the first time it is demonstrated that the palladium-catalyzed amidocarbonylations of aldehydes can be run with significantly lower halide concentrations (a major yield decrease. While phosphine-free catalyst systems give best yields at low CO pressure, phosphine-ligated palladium catalysts lead to better yields at higher CO pressure. At low palladium loadings (0.1 mol %), unwanted condensation reactions of propionaldehyde become increasingly competitive.

7-AMINOIMIDAZOTRIAZONES

The invention relates to novel 7-amino-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

5-ETHYL-IMIDAZO (5,1-F) (1,2,4,) TRIAZIN-4 (3H) -ONES AS PHOSPHODIESTERASE INHIBITORS

The invention relates to novel 5-ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

5-ETHYLIMIDAROTRIAZONES

The invention relates to novel 5-ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

Substituted imidazotriazinones

The present invention relates to new substituted imidazotriazinones, processes for their preparation, and their use for the production of medicaments, in particular for improving perception, concentration power, learning power and/or memory power.

STUDIES ON HYDROCARBOXYLATION OF N-ACETYLIMINES, ENAMINES AND ALLYLAMINES.

Treatment of an amide with an aldehyde in the presence of Co2(CO)8/CO/H2 results in N-acyl-α-amino acids. The scope and limitations of this reaction are explored

Racemic Structures of Organic Ammonium Salts of N-Acetyl-DL-2-aminobutyric Acid and N-Acetyl-DL-norvaline and Optical Resolution by Preferential Crystallization of DL-Ammonium Salts

The racemic structures of the ammonium salts (AM salts) and seven organic ammonium salts of N-acetyl-DL-2-aminobutyric acid (Dl-AcAbu) and N-acetyl-DL-norvaline (DL-AcNva) were studied on the basis of thermodynamic analyses to explore the possibility of optical resolution by preferential crystallization.An empirical equation has been derived from thermodynamic data and melting points of ammonium and organic ammonium salts of N-acyl-DL-amino acids to predict racemic structure around room temperature.The AM salts of DL-AcAbu and -AcNva exist in conglomerate around room temperature.It is possible to resolve optically these DL-AM salts by preferential crystallization in ethanol at 10 deg C, and the succesive preferential crystallization followed by purification gave D- and L-2-aminobutyric acids and -norvalines with optical purities close to 100percent.